Immuno

Question 1

IFN-12

Answer 1

• released by NK cells and Th1 cells
• Host cell mediated defense
• IL-12 secretion by a infected macrophage( in this case a intracellular mycobacterium )
• IFN then binds to receptor on the macrophage leading to dimerization and activation of the Janus Kinases 1 and 2.
• Results in nuclear signalling via STAT1 and transcription of IFN-gamma regulated genes

Question 2

X-linked agammaglobinemia

Answer 2

• Bcell immunodeficiency
• Prone to Giardia Lamblia infection
• and recurrent respiratory infections

Question 3

C3 deff

Answer 3

• recurrent infections from encapsulated organisms

Question 4

C5-C9 deff

Answer 4

• components of the membrane attack complex

- recurrent infections of Niesseria Gonorrhoeae or meningitidis.