Immunizations Flashcards
Influenza vaccines available
IIV4, RIV4 or LAIV4
Influenza recommended ages
> 6 months (IIV4)
18 years (RIV4)
2 to 49 years (LAIV4)
Influenza dosing
1 dose annually during September/October
Children 6 months through 8 years who have only received one or no lifetime doses require 2 doses >4 weeks apart
Influenza efficacy
~50%, reduces symptomatic illness, medical visits, hospitalization, and death.
Immunity delayed 2 weeks after vaccination
Influenza contraindications
IIV4 and LAIV: h/o anaphylaxis
LAIV4 ONLY: Pregnancy, immunocompromise, children aged 2-4 yo w/ asthma, children/adolescents treated w/ aspirin/salicylates (risk of Reye syndrome), treatment with influenza antivirals within past 48 hours
Why is influenza vaccine modified annually?
Antigenic drift
What is antigenic drift
Gradual protein changes
What is antigenic shift
Drastic protein changes
Can you get the flu vaccine with an egg allergy
Heck yeah, get the cell-cultured or recombinant
COVID-19 vaccines available
Pfizer (COMIRNATY)
Moderna (SPIKEVAX)
Novavax
Recommended ages
Pfizer: 6 mo - 4 yo = yellow cap, 5 -11 yo = blue cap, 12+ yo = grey cap
Moderna: 6 mo - 11 yo = green label, 12+ yo = blue label
Novavax: 12+ yo = syringe
COVID-19 vaccine dosing
See dosing chart in notes
COVID vaccine efficacy
~90%
COVID-19 Contraindications
h/o anaphylaxis or an immediate allergic reaction to vaccine ingredients, including PEG
COVID-19 vaccine ADRs
Myocarditis and pericarditis (rare), most common in adolescents and young adult males. Mainly injection site reactions (pain, fever, fatigue).
Pneumococccal vaccines available
PCV15, PCV20, PPSV23
Pneumococcal recommended ages
PCV: >/= 6 weeks
PPSV: >/=2 years
Pneumococcal ADRs
Rare: febrile seizures in children when administered with IIV
Pneumococcal vaccine special considerations
Patients with asplenia are at a higher risk for invasive pneumococcal disease and require vaccination
When administering PCV15 and PPSV23, do the PCV15 first.