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Patho > Immunity > Flashcards

Immunity Flashcards

1
Q

A pathway of complement system that is directly initiated by nonimmunologic stimuli, such as an invading microorganism?

A

Alternate Pathway

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2
Q

A type of HLA antigen that is chiefly found on immunocompetent cells?

A

Class II antigen

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3
Q

Allergic reaction, anaphylaxis and angioedema are examples of this type of hypersensitivity.

A

Type I Immediate Hypersensitivity

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4
Q

A type of hypersensitivity wherein complement-fixing antibodies react with antigens which results in cell lysis and destruction? Give example

A

Type II Cytotoxic Hypersensitivity

e.g Hemolytic Transfusion reaction, Goodpasture syndrome, Graves disease

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5
Q

A type of hypersensitivity wherein exogenous antibodies produced in response to exposure to an antigen combines with antigen resulting in antigen-antibody complexes which are then deposited at vessels walls or serosal surfaces? Give example.

A

Type III Immune Complex Hypersensitivity

eg. Serum Sickness, SLE

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6
Q

A congenital T-cell deficiency resulting from aberrant embryonic development of the 3rd and 4th branchial pouches?

A

DiGeorge Syndrome

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7
Q

This condition is due to failure of antibody synthesis caused by block in maturation of pre-B cells to B cells due to a mutation i the B cell tyrosine kinase (Btk) gene?

A

X-linked agammaglobinemia of Burton

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8
Q

A pathway of the complement system that is initiated by antigen-antibody complexes?

A

Classical Pathway

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9
Q

A condition with marked deficiency of both T and B cells?

A

Severe combined immunodeficiency disease (SCID)/ Swiss-type agammaglobinemia

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10
Q

An X-linked disorder with mutation in WASP gene for actin filament assembly characterized with eczema, thrombocytopenia, recurrent infections and poor antibody response to polysaccharide antigens?

A

Wiskott-Aldrich Syndrome

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11
Q

ANA with anticentromere activity is specific for what PSS variant?

A 
CREST Syndrome
Calcinosis
Raynaud Phenomenon
Esophageal dysfunction
Sclerodactyly
Telangiectasia
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12
Q

The antinuclear antibody that is most specific for SLE?

A

Anti-Sm (Smith)

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13
Q

What is the triad of Sjogren Syndrome?

A 
Xerostomia (dry mouth)
Keratoconjunctivitis sicca (dry eyes)
One of several connective tissue or autoimmune disease
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14
Q

The antinuclear antibody most specific for Sjogren Syndrome?

A

Anti-SS-A

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15
Q

A disease characteristically stained with Congo Red dye and demonstrate an apple green birefringence under polarized light?

A

Amyloidosis

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16
Q

Where is the gene that codes for protein precursors of A4 amyloid seen in Alzheimer’s disease?

A

Chromosome 21

17
Q

A condition caused by deposition of amyloid fibrils derived from immunoglobulin light chains referred to as AL protein?

A

Primary Amyloidosis (Immunocytic Dyscrasia Amyloidosis)

18
Q

Deposition of fibrils consisting of the amyloid protein called AA protein from a precursor serum amyloid-associated protein (SAA)?

A

Secondary amyloidosis ( Reactive Systemic Amyloidosis)

19
Q

An autoimmune disease wherein gliadin stimulates cytotoxic attack on enterocytes causing villous atrophy, manifested with diarrhea and steatorrhea?

A

Celiac Disease

20
Q

Distinguishing feature if drug-induced SLE?

A

Anti-histone Antibodies

21
Q

What drugs are used to treat Sjogren Syndrome?

A

Corticosteroids
Artificial Tears
Pilocarpine

22
Q

Presence of this antibody is specific for Diffuse Scleroderma.

A

Anti-Scl70 (Anti-topoisomerase)

23
Q

Antibody specific to Mixed Connective Tissue Disease?

A

Anti-RNP (Anti-Ribonucleoprotein)

24
Q

Treatment for acute humoral rejection in transplanted organs?

A

B-cell depleting agents

25
Q

An autosomal recessive disease characterized with failure of phagolysosomal fusion leading to impaired neutrophil chemotaxis?

A

Chediak-Higashi Syndrome

26
Q

What is the most common complement defect?

A

C2 Deficiency

27
Q

A condition with specific deficiency in C5-C9 of the complement system leading to inability to form membrane-attack complexes?

A

Terminal Complement Deficiency

28
Q

What is the confirmatory test for HIV?

A

Western Blot

29
Q

What is the most sensitive test for diagnosis os acute HIV before seroconversion?

A

HIV viral load

30
Q

What level of protein structure is abnormal in systemic amyloidosis?

A

Secondary B pleated sheet

31
Q

Protein responsible for amyloidosis seen in Type 2 DM?

A

Amylin

Patho (9 decks)

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