Immune System Cells

Question 1

Leukocytes

Answer 1

WBC that help defend the body vs diease, remove wastes, toxins and damages/abnormal cells

Question 2

Basophils

Answer 2

Granulocytes: release H1 to vasodilate, increase permeability of capillaries

Question 3

Eosinophils

Answer 3

Granulocytes: defends against parasites and worms consumes the immune complex via phagocytosis
Part of the nonspecific internal defense
Cause Tissue damage.

Question 4

Neutrophils

Answer 4

Granulocyte that is most abundant in the blood they are not present in healthy tissues. Engulf microbes by phagocytocis.

Question 5

Erythrocytes

Answer 5

RBC agranulocytes that will transfer O2 and CO2 to tissues

Question 6

Monocytes

Answer 6

Agranulocytes: give rise to macrophages they consume bacteria by phagocytosis, release cytokines and call other immune cells to the site of infection. DC cells are also monocytes

Question 7

Lymphocytes

Answer 7

Bcells: produce plasma to create antibodies and memory cells to recognize 2nd infection
Tcells: kills cells not recognize as self or that are cancerous.

Question 8

Natural K cells

Answer 8

• Directly kills virus and other abnormal cells
• Stimulated by type I INF in response to a viral infection
• release innate cytokine TNFa and adaptive cytokine INFgamma
• No specific antigen but keep viral infection at bay until adaptive immune response can kick in
• Part of the non specific internal defense

Question 9

Inflammatory Response

Answer 9

-Rubor(redness)
-Calor (heat)
-Dolor (pain)
-Tumor (swelling)
rose help peter study
-Activated by injured tissue to destroy invaders and repair tissue
-Non specific internal defense

Question 10

Increase Blood Flow

Answer 10

• non specific internal defense

- caused by mast cells and basophils that release H1

Question 11

Fever

Answer 11

• Non Specific internal defense that resets the brain’s thermostat to a higher temperature.
• increase immune response
• decrease bacterial infection

Question 12

Positive selection

Answer 12

Select Tcells that bind relatively well to self MHC in the Thymus cortex. Positively selected cells survive and proliferate.

Question 13

Negative Selection

Answer 13

ID cells that binds too strongly to the self MHC and eliminate them this happens in the medulla of the thymus. after negative selection the cell that survived can now leave the thymus and are called self tolerant naive tcells.

Question 14

Regulatory T cells (Treg)

Answer 14

• CD4 tcell
• express CD25
• suppress proliferation of naive tcells that responds to self antigens by acting and binding to the APC those rogue Tcells were going to bind to
• Suppress autoreactive Tcells
• Secrete anti inflammation cytokines
• Prevent DC’s from reacting with additional naive t cells
• Direct contacts with effector Tcells

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Question 15

Dendrites

Answer 15

APC that will migrate to the LN and present the antigen to the Tcells.
-Needs co stimulation with its B7 and CD 28 of the Tcell in order to stimulate proliferation and differentiation of Tcells

Question 16

Macrophages

Answer 16

Doesnt migrate to the LN its an APC that has a specifi location. bind to circulating Tcells that passes by it.

Question 17

Rhogam

Answer 17

Purified human anti RhIgG given to pregnant women to coat baby’s RBC when entering the mom’s circulation. This prevents the naive B cells of mom to be activated and forming high affinity IgG.

Question 18

Monoclonol antibody Treatment

Answer 18

• Act just like our humoral immune system
• Specifically targets antigens, their functions and their distributions. Can be conjugated with catalytic toxins, radiation or chemotherapy agents to target specific tissues,