Hematopoietic and Thrombopoietic Drugs

Question 1

Erythropoietin

Answer 1

Released by Kidney in response to low O2 in the blood supply. This in turn will act on the red bone marrow to release more RBCs. RBCs will increase the O2 supply in the blood which will decrease erythropoietic release.

Question 2

Procrit and Epogen

Answer 2

These are rhuEPO glycoprotein hormone. Used for anemia

Question 3

Darbopoeitin

Answer 3

Heavily glycosylated epoeitin with 2-3x longet t1/2 than procrit or epogen. Used for anemia

Question 4

EPO adverse effects

Answer 4

HTN
Clotting complications
Pure red cell aplasia (PRCA): neutralizing antibodies to EPO

Question 5

Filgrastin

Answer 5

• Neupogen
• Binds to the receptor to increase neutrophil levels by acting on G-CSF (hormone that increase WBC counts)
• Act through the JAK/STAT pathway
• ADE: pain on inj site, bone pain, sickle cell crisis
• pegfilgastrim is longer acting alternative

Question 6

Sargromastin

Answer 6

• Acts on the GM-CSF to increase the numbers of granulocytes as well as monocytes.
• Also can bind to IL-2 to stimulate Tcell proliferation
• ADE: fever, arthragia, myalgia, capillary leak syndrome

Question 7

IL-11

Answer 7

-oprelvekin (neumega)
-usually made by fibroblast and stromal cells in the bone marrow
-stimulate the growth of megakaryocyte progenitors
ADE: fatigue, headache, dizz, CV effects anemia, and SOB

Question 8

Romiplastim

Answer 8

-NPlate
-Peptibody thrombopoeitin analog that act om MPI (thrombopoeitin receptor) to increase platelet count
-Dose dependent increase in platelet count
ADE: headache on the day of admin