Immune system

Question 1

what are the 4 components of the nonspecific/innate immune system?

Answer 1

low ph
protection
chemicals
phagocytic and degrading cells

Question 2

what type of proteins are antibodies?

Answer 2

glycoproteins

Question 3

what is the most common antibody?

Answer 3

IgG

Question 4

which antibody can cross the placenta?

Answer 4

IgG

Question 5

which antibody is pentameric?

Answer 5

IgM

Question 6

which antibody cannot cross the placenta?

Answer 6

IgM

Question 7

which antibody is the 1st to appear in an immune response?

Answer 7

IgM

Question 8

which antibody is dimeric?

Answer 8

IgA

Question 9

which antibody is found in secretions?

Answer 9

IgA

Question 10

which antibody is found on the surface of mast cells?

Answer 10

IgE

Question 11

which antibody is found in allergic diseases?

Answer 11

IgE

Question 12

which antibody acts on the cell surface?

Answer 12

IgD

Question 13

which antibody promotes the maturity of the immune system?

Answer 13

IgD

Question 14

what are clusters of differnetiation moleculss?

Answer 14

help to characterise cell types and expressed by cells in different stages of differentiation

Question 15

MHC molecules are products of what??

Answer 15

supergene at chromosome 6

Question 16

expression of MHC’s are specific to what 3 things?

Answer 16

the cell, tissue type, and degree of differentiation

Question 17

MHC I is on the surface of what cells?

Answer 17

platelets and all nucleated cells

Question 18

MHC II is on the surface of what cells?

Answer 18

APC’s and B lymphocytes

Question 19

MHC I cells presents atg to what cells?

Answer 19

cytotoxic t cells

Question 20

MHC II cells presents atg to what cells?

Answer 20

t helper cells

Question 21

which antibody is at high levels during the primary immune repsonse?

Answer 21

IgM

Question 22

which antibody is at high levels during the secondary immune response?

Answer 22

IgG

Question 23

what is the humoural immune response mediated by?

Answer 23

specific antibodies that directly act on the antigen

Question 24

what is the cell-mediate immune response mediated by?

Answer 24

specific t lymphocytes that attack and destroy virus-infected host cells of foreign cells

Question 25

what type of immunity is responsible for transplant rejection?

Answer 25

cell-mediated

Question 26

what characterizes central lymphoid organs?

Answer 26

organ where cells originate and differentiate from

Question 27

what characterizes peripheral lymphoid organs?

Answer 27

organ where cells further differentiate, proliferate, and execute immune response

Question 28

which are the 3 central lymphoid organs?

Answer 28

thymus, bone marrow, and galt

Question 29

which are the 6 peripheral lymphoid organs?

Answer 29

``` spleen tonsil lymph node solitary lymph nodule peyer's patches appendix ```

Question 30

which are the encapsulated lymphoid organs?

Answer 30

thymus lymph nodes spleen

Question 31

what makes 85% of the total lymphoid mass?

Answer 31

MALT

Question 32

what makes 12% of the total lymphoid mass?

Answer 32

encapsulated organs

Question 33

what makes 5% of the total lymphoid mass?

Answer 33

bone marrow and circulating lymphoid cells

Question 34

70% of circulating lymphocytes are what kind of cells? what is their function?

Answer 34

immunopotent cells- most are T cells survey and circulate tissues

Question 35

where do b cells differentiate?

Answer 35

bone marrow and galt

Question 36

what are the 5 markers of B cells?

Answer 36

CD 9, 19, 20 BCR MHC II

Question 37

In immature B cells, what type of BCR is presnet?

Answer 37

IgM

Question 38

In mature B cells, what type of BCR is present?

Answer 38

IgD

Question 39

where do t cells differentiate?

Answer 39

thymus

Question 40

what are the 7 markers of T cells?

Answer 40

CD 2, 3, 5, 6, TCR CD4 or CD8

Question 41

TH1 cells secrete what 3 cytokines?

Answer 41

IL-2, TNF- alpha, IFN- gamma

Question 42

TH2 cells secrete what 4 cytokines?

Answer 42

IL4, 5, 10, 13

Question 43

TH1 cells interact with what cells?

Answer 43

cytotoic CD8+ T cells, NK cells, and macorphages

Question 44

TH2 cells interact withw hat cells?

Answer 44

B lymphocytes

Question 45

TH1 cells control extra or intracellular pathogens?

Answer 45

intracellular

Question 46

TH2 cells control extra or intracellular pathogens?

Answer 46

extracellular

Question 47

TH1 cells are involved in what type of immune response?

Answer 47

cell mediated

Question 48

TH2 cells are involved in what type of immune response?

Answer 48

antibody mediated