Hematopoeisis

Question 1

where do blood cells form from during the 1st week of development?

Answer 1

yolk sac

Question 2

where do blood cells form from during the 3rd-7th month of development?

Answer 2

liver (mostly) / spleen

Question 3

where do blood cells form from during the 5th-7th month of development?

Answer 3

bone marrow

Question 4

where do blood cells form from by 10 years of age?

Answer 4

ribs, sternum , pelvis, proximal epiphysis of femur and humerus

Question 5

which type of bone marrow is made mainly by haemopoietic cells?

Answer 5

red bone marrow

Question 6

haemopoietic cells and macrophages organize into what?

Answer 6

haematopoietic cords

Question 7

what separates haemoatopoietic cords?

Answer 7

sinusoids

Question 8

stroma consists of what cells and fibres?

Answer 8

reticular cells (reticular adventitous cells) and reticular fibres

Question 9

which type of bone marrow contains growth factours?

Answer 9

red bone marrow

Question 10

what do pluripotent stem cells look like?

Answer 10

large lymphocytes

Question 11

lymphocytes form from what colony forming unit?

Answer 11

CFU-Ly

Question 12

basophils, eosinophils, erythrocytes, and platelets form directly from what colony forming unit?

Answer 12

CFU-GEMM

Question 13

neutrophils and macrophages form directly from what colony forming unit?

Answer 13

CFU-GM

Question 14

erythropoiesis is stimulated by what hormone?

Answer 14

erythropoietin

Question 15

where does erythropoietin come from?

Answer 15

interstitial cells from cortex of kidney

Question 16

what 3 things does erythropoiesis require in order to function?

Answer 16

vitamins (b6, b12, c, e, folic acid, riboflavin, panothenic acid, thiamin)
metals (fe, co, mn)
amino acids

Question 17

precursor cells of rbc have what type of nucleus?

Answer 17

round cell

Question 18

what happens to the cytoplasm of cells during erythropoiesis?

Answer 18

becomes homogenous

Question 19

how many days does it take for erythropoiesis to complete?

Answer 19

7 days

Question 20

recite the order of precursor cells to erythrocyte

Answer 20

proerythroblast
basophilic erythroblast
polychromatic erythroblast
ortochromatic erythroblast
reticulocyte
erythrocyte

Question 21

which rbc precursor is the last to be nucleated?

Answer 21

ortochromatic erythroblast

Question 22

during granulocytopoeisis, what happens to the nucleus?

Answer 22

it becomes indented, non-round, multilobulated

Question 23

the mitotic phase of granulocytopoeisis occurs for how long?

Answer 23

7 days

Question 24

the non mitotic phase of granulocytopoeisis occurs for how long?

Answer 24

7 days

Question 25

which cell type does specific granules first appear during granulocytopoeisis?

Answer 25

myelocyte

Question 26

what are the 3 precursor cells in the mitotic phase of granulocytopoeisis?

Answer 26

myeloblast promyeloblast myelocyte

Question 27

what are the 3 precursor cells in the non mitotic phase of granulocytopoeisis?

Answer 27

metamyelocyte band mature granulocyte

Question 28

thrombocytopoiesis is stumlate by what hormone?

Answer 28

thrombopoietin

Question 29

recite the 4 steps of cell formation during thrombocytopoiesis

Answer 29

megakaryoblasts endomitosis megakaryocytes platelets released by cytoplasmic fragmentation

Question 30

what occurs during endomitosis in thrombocytopoeisis?

Answer 30

chromosome divide, cells do not (increase in size) | can have up to 64n inside cells