Immune System Flashcards
Immune System
functional system, not an organ sys.
-prevent disease causing agents from infecting us by getting into the body.
Two Components of the Immune Sys.
- Innate
- Adaptive
Innate immunity is_________
nonspecific
Adaptive immunity is________
specific
Pathogen
disease-causing microorganisms
Antigen
-the body doesn’t distinguish a diseased antigen from a non diseased one.
Nonspecific immunity
- always prepared
- attacks anything and everything foreign
Innate Immune Sys
- intact skin and mucosae
- phagocytes
- NK cells
- inflammation
- antimicrobial proteins
- fever
when skin barriers are breached it leads to________
inflammation
Specific immunity
- specific and adaptive
- uses B & T lymphocytes
- goes after specific pathogens
The first line of defense consists of______
the surface barriers:
- INTACT skin and MUCOSAE
when the first line of defense is penetrated, the second line of defense comes into play; the second line of defense consists of__________
internal defenses:
-phagocytes; NK cells; inflammation; antimicrobial proteins; fever
the hallmark of the second line of defense is ______
inflammation
the third line of defense is the _______
adaptive immune sys.
broken skin equals a______
point of entry
mucous membranes line and_____
“trap”
-functions with acidity to produce an harsh acidic environment
TWO types of macrophages:
- Free
- Fixed
Free macrophages______
wander in tissue spaces in search of cellular debris or “foreign invaders”
Fixed macrophages_______
ex: such as stellate macrophages in the liver are permanent residents of particular organs
superficial nonspecific immunity have______
enzymes that breaks things apart; more specific lysozymes that destroy bacteria
internal nonspecific defenses consists of ________
- phagocytes
- mast cells
- NK cells
- inflammation
- antimicrobial proteins
- fever
phagocytes work through phagocytosis and are_____
-macrophages; neutrophils; eosinophils
macrophages
the most voracious; “big eaters”
neutrophils
become phagocytic encountering infectious material in tissues
mast cells
bind to, ingest, and kill bacteria; semi-phagocytic manner; release histamine
histamine is a_____
potent inflammatory chemical
NK cells
type of t-lympho that is not specific; interact and kill; go after our own cells that are damaged, infected, or invaded with a virus
inflammation has 4 cardinal signs, they are_____
- heat
- redness
- swelling
- pain
inflammation surrounds the area infected and keeps it_______this alerts the_______ and sets the stage for_____
localized;
adaptive immune sys.;
repair
antimicrobial proteins ______
attack microorganisms by either killing them or eliminating their ability to reproduce
types of antimicrobial proteins_____
interferons and complement
interferons
chemical released by infected cells, the chemicals diffuse to neighboring cells to protect them from the intruder;
-not specific
complements sys. protein
a group of at least 20 plasma proteins that circulate in blood inactive and then when activated it stimulates inflammation
the complement sys . enhances both the______
innate and adaptive defenses
fever
a systemic response to antigens
Phagocytic Mechanism
- a phagocyte recognizes a pathogen’s carbohydrate surface markers ; enhanced in opsonization
- cytoplasmic extensions adhere to pathogen
- pathogen pulled inside the cell in a vacuole called a phagosome
- lysosome binds w/phagosome to form phagolysosome
- lysosomal enzymes digest pathogen and can be aided by respiratory burst if need be for resistant bacteria such as TB and certain other bacteria
- residual body formed and then expelled
NK mechanism
- detect infected or cancerous cells through abnormalities such as a lack of “self” markers called MHC proteins or the presence of certain sugars
- release perforins that punch holes in the cell
- channels appear in target cells and nucleus disintegrates
- attack directly by inducing apoptosis
nk cells are not______or_____
phagocytic or specific
nk cells are not______or_____
phagocytic or specific
inflammatory mechanism
nonspecific response to any tissue injury
- toll-like receptors on macrophages recognize pathogens
- toll-like receptors release cytokines (Cell chemicals) which attract antibodies (positive chemotaxis)
- other cells release other inflammatory mediator chemicals
- vessels in injured area dilate and increase permeability
- hyperemia occurs
- exudate accumulates at site to cause edema (swelling)
dilation causes_______
hyperemia
increased permeability causes____
exudate