immune responses Flashcards
1
Q
3 ways that complement is activated
A
classical- IgM, IgG
MBL- microbial surfaces
Alternative- microbial surfaces
2
Q
C3b function
A
opsonin
3
Q
C3a, C5a function
A
anaphylaxis
4
Q
C5a activity
A
neutrophil chemotaxis
5
Q
two main opsonins in bacterial defense
A
C3b, IgG
6
Q
C1 esterase deficiency
A
causes hereditary angioedema
7
Q
C3 deficiency (2)
A
severe, recurrent sinopulmonary infections (especially S pneuma, H influenza)
increased susceptibility to type III HST reactions
8
Q
C5-9 deficiency
A
increased susceptibility to neisseria infections
9
Q
DAF deficiency
A
anchored to membrane by GPI, lack = complement-mediates lysis of RBCs
10
Q
clinical consequence of DAF deficiency
A
thrombosis d/t platelet granule release
