cytokines

Question 1

cytokines secreted by macrophages

Answer 1

IL- 1, 6, 8, 12, TNFa

Question 2

activity of IL-1 (2)

Answer 2

induces fever

activates endothelium to express adhesion molecules

Question 3

activity of IL-6 (2)

Answer 3

causes fever

stimulates production of acute phase reactants

Question 4

activity of IL-8 (1)

Answer 4

neutrophil chemotaxis

Question 5

activity of IL-12 (2)

Answer 5

induces Th cells to be Th1 cells

activates NK cells

Question 6

activity of TNFa (3)

Answer 6

mediates septic shock, activates endothelium, vascular leakage

Question 7

secreted by all T cells (2)

Answer 7

IL-2, 3

Question 8

activity of IL-3

Answer 8

functions of GM-CSF= promotes growth and differentiation of bone marrow stem cells

Question 9

secreted by Th1 cells (2)

Answer 9

IFNg and IL-2

Question 10

activity of IFNg (3)

Answer 10

activates macrophages
increased Th1 response
suppresses Th2 response

Question 11

From Th2 cells (3)

Answer 11

Il-4, 5, 10

Question 12

antiviral activity of interferons

Answer 12

place uninfected cells in an antiviral state by producing a ribonuclease that inhibits viral protein synthesis

Question 13

CD14

Answer 13

marker on macrophages that binds LPS