immune responce Flashcards
2 types of immune responce ?
innate and adaptive
which is first?
innate
what is the first cell type ?
pluripotent hematopiethic stem cells in bone marrow
what two paths can pluripotent hematopoietic stem cells take ?
common lymphoid progen or myeroid
what do common lymphoid porgen turn into ?
T, B and NK , AND DENTITIC
what do common myeroid progen turn into ?
macrophages (neutorphils ,eosinophils, mast cells, monocytes) or erythrocytes
what are the primary immune tissues?
thymus and bone marrow
what are the secondary immune tissues?
spleen, lymph nodes adenoids and tonsils
3 main steps in infection time line ?
establish infection ( fights with innate), induction of adaptive, adaptive
what are B cells activated by ?
antigen and t cells, to get a full response need cytokines and receptor activation
3 main ways antibodies can kill pathogen?
neutralisation, opsonisation and complement activation
what happens in neutralisation?
prevents adhesion to cells
what happens in opsonisation?
promotes phagocytosis
what happens in complement activation?
enhances opsonisation and lyse bacterial protein punches membrane
how are unique antibodies produced?
conbination of diff genetic sections - diff protein receptor
and somatic hypermutation- specific changes to binding pocket