Immune Memory and Vaccination Flashcards
The immune response improves over time
- antibodies developed during the primary response provides protective immunity
- new adaptive immune response is not activated
- serum levels decline with time
what are the 3 adaptive memory cells
memory B cells
memory plasma cells
memory T cells
-central (in secondary lymph nodes)
-Effector (in the periphery)where can you find memory cells in the body(there are 4)
bone marrow(plasma cells)
secondary lymph nodes(central cells)
peripheral tissues(effector)
circulation
where do memory cells develop?
in the secondary lymphoid tissue
T/F memory cells mirror pathogen specific effector cells for example: Th17, CD4, memory T cells
True
characteristics of primary effector cells
broad antigen response multiple activation steps clonal selection and expansion under go target refinement -Somatic hypermutation -class switching cannot undergo hypermutation again die after several days
characteristics of memory cells
specific, restricted antigen response easily activated clonal expansion B cell target refinement unnecessary may undergo somatic hypermutation persist for months and replicate -long term immunity
Immune memory can persist for decades
pathogen and exposure-dependent
does not depend upon antigen persistence
steady-state serum antibody levels
persistence is highly variable across diseases
The secondary immune response does what to memory cells and what to naive B cells?
activate memory
inhibits naive cells
What happens when a naive B cells binds pathogen coated with specific antibody?
inhibits the naive B cell
What happens with a Memory B cell binds a pathogen that is coated with a specific antibody?
activates the memory B cell
Activated memory B cells replicate into plasma cells and more memory cells, can they form cognate pairs with memory Tfh cels?
yes
what happens when a memory B cell and a memory Tfh meet up?
form germinal centers class switch SMH **create a Ab with a now higher affinity for the antigen this is what vaccine boosters do
Memory T cells types
CD8 and all of the CD4 subtypes
do memory T cells require CD28 co-stimulation?
nope
