Immune evasion and subversion pt 2 Flashcards

1
Q

T and B cells bearing receptor that recognize self-antigens are eliminated

A

clonal deletion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T-Cells clonal deletion

A

-must bind to MHC but not self antigen
-Fails to recognize self MHC eliminate
-Passes but does not react well with self-antigen it will be eliminated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Schistosome mansoni outer covering

A

tegument

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Schistosome mansoni taking advantage

A

It takes adavtange of nonresponse to self by absorbing host proteins onto their tegument to make it look like it apart of own tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

T. vaginalis taking advantage

A

Encodes surface in proteins that are similar to the host proteins so it does not trigger a strong immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Straegy used by parasties to evade the host’s immune system by altering the proteins or antigens on their surface

A

Antigenic variation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Trypanosoma brucei using variant surface glycoprotein

A

Have over a thousand copies of VSG but only express 1 at a time
VSG into the membrane and a variable region exposed to antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Antigenic Variation works

A

Pseudogene are inactive due to the lack of promoters
Only one site is expresses at a time
Then a new VSG gene is copied from the pseudogene pool and transposed into the expression site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does this affect antibodies

A

Antibodies from previous VSG proteins become ineffective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How often does antigenic switich occur

A

about every 100 generations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How does antigenic variation affect immune response

A

Allows parasite to avoid detection by immune cells targeting specific antigens
Allows for reinfection of previously infected hosts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly