Immune Disorders: Immunity & Allergy Flashcards
TLR recognize extra ou intra cellular pathogen? trasnmembrane
Extra
It is a transmembrane PRR
NLR or RIG-1 are extra or intra PRR?
Intra
Cytosolic PRR
NLR activate what?
It is associated w which diseases?
Examples
Inflammasone
Immunological diseases
Chron’s
Asthma
RIG-1 kill what type of pathogen?
Viruses
Macrophage activated by PRR secrete a large amount of what?
Promote what?
TNF-a
Inflammation
Suppress by Treg/CD4
When TNF-a remain high=systemic infla=SEPSIS=death
E coli prod TCPC. What does it inhibits
TLR signaling of dentritic cell
Dysbiosis
Imbalance in bacterial flora
Increase pro infla bact = infection (increase Th17)
Decrease anti-infla bact = infection/immunological disorders (decrease Treg)
Type 1 hypersensitivity reaction.
Helminths (worm) produce….
That inhibit mast cell…
Which inhibit….
ES-62
TLR
Degranulation
Food allergies (type 1) Gluten is metabolized into ..... Antibodies prod against .... = ....... disease
GLIADIN
Celiac disease
Peanut allergie (type 1) is so small that it could be ……
Airborne
In systemic anaphylaxis
There is a massive mast cell degranulation
What are the s/s
How to tx?
BP drop
Increase HR
Airway obstruction
Epi
Corticosteroid to minimize late phase reaction
Epi
How does it work?
Trigger sympathetic nervous syst
vasoC
BronchoD
Give 3 examples of type 4 delayed sensitivity
Contact dermatisis
Polymyositis
Sympathetic ophtalmia
- Sensitivity to metals
CD4->macro activation
Delayed reaction
May give rise to GRANULOMATOUS INFLAMMATION - CD8
- Trauma to 1 eye release antigen
Antigen travel to lymph node
T cells go to both eyes (don’t know where it’s coming from )
That’s why they take out the eye rapidly to save the good one
