Immune Diseases - ITP

Question 1

What is ITP

Answer 1

Attack directed against platelets; Type II hypersensitivity

Question 2

Causes of thrombocytopenia

Answer 2

Decreased production, Sequestration, Consumption, Destruction
Don’t make them, hide them, use them, destroy them
(Loss from bleeding is NOT usually a cause of thrombocytopenia)

Question 3

Signalment of ITP (age, sex & breed)

Answer 3

Middle aged
Female > male
Cocker spaniel, Poodle, ANY

Question 4

ITP historical finding include

Answer 4

Acute or Insidious
Observation of bleeding
Consequences of bleeding
Site related signs
Drug or vaccine history

Question 5

ITP physical findings

Answer 5

Petechiae, Ecchymosis, Retinal Hemorrhage, Epitaxis, Melena, Pallor, Fever, Spenomegaly, Site related signs

Question 6

Signs of anemia in ITP

Answer 6

Pallor, weakness, anorexia, tachypnea

Question 7

Worse site of bleeding in ITP

Answer 7

The Brain

Question 8

ITP hematologic observations

Answer 8

Anemia (regenerative with time) 
Marked thrombocytopenia
\+/- large platelets
Hypoproteinemia
Mild leukocytosis
Absence of inclusions

Question 9

ITP biochemical profile

Answer 9

Related to bleeding

TP, albumin, BUN

Question 10

ITP urinalysis

Answer 10

Hematuria

Question 11

ITP coagulation assay

Answer 11

Prolonged ACT

Normal PT and PTT

Question 12

IPT ID screens

Answer 12

Rickettsial types

Question 13

ITP bone marrow cytology

Answer 13

Megakaryocytosis

Question 14

Immunologic tests of ITP

Answer 14

Platelet factor 3
Antimegakaryocytic antibody
Flow cytometric assay
NOT Coombs - Evans syndrome
NOT ANA - SLE

Question 15

Treatment of ITP

Answer 15

Corticosteriods - high dose, slow taper
Vincristine - low dose
Cytotoxic drugs, IVIG
Splenectomy
Plasmapheresis
Transfusion?
\+/- tetracycline
No need for vit K