Immune And Lymphatic System Flashcards
What is the response of innate immunity? And why is that?
Inflammation because it lacks immune specificity and memory
What are the first responders of innate immunity?
Neutrophils
Acquired immunity develops in response to antigens? What does this signify?
Specificity and memory
Passive immunity is a temporary immunity due to donated what?
Antibodies
Active immunity is a long-lasting/permanent immunity due to self exposure to antigen resulting in?
Memory T cells and B cells specific for antigen
What are the primary lymphoid organs
Thymus and bone marrow
What are the secondary lymphoid organs?
Lymph nodes, spleen, tonsils
Are spherical, tightly packed accumulations of virgin B cells and dendritic reticular cells that have not been exposed to antigens, describes what?
Primary follicles
Are derived from primary follicles that have been exposed to non-self antigens, and not present at birth describes?
Secondary follicles
Lymph follicles are sites of B cell localization and proliferation. T/F?
True
Subcutaneous-associated lymphoid tissue is found in the __ layer of the dermis
Papillary
Aggregated lymphoid tissue is beneath and in contact with the epithelium which includes…
Various tonsils and Peyer’s patches in the ileum
IgA are found where?
Saliva, milk, GU and respiratory tracts
IgD are found where?
On surfaces of B cells traveling to lymphoid organs
IgG responsible for?
Responsible for most antibody activity
IgE associated with what type of responses?
Allergic responses
IgM is the first antibody class expressed by developing __ cells?
B cells
What is the main function of major histocompatibility complex? (MHC)
Present antigenic peptides to T cells
CD8 sis a member of what superfamily?
Ig superfamily
Cd4+ T cells are helper cells that assist in __ cell differentiation
B cell
CD8+ T cells release…
Perforins and Fas ligand
CD16+ T cells aka
Natural killer T cells
Dense collagen fibers, some elastic fibers, and smooth fibers describe what part of a lymph node?
Capsule
What is the entry and exit point for vessels in a lymph node?
Hilus
The outer cortex of a lymph node contains what?
Lymph follicles
The cortex follicles of a lymph contain: B cells, follicular dendritic cells, and migrating dendritic cells. T/F?
True
The deep (inner) cortex of a lymph node contain HEVs. T/F?
True
The medulla of a lymph node is the site of lymphocyte reentry into lymph stream? T/F?
True
Medulla or lymph node is an irregular arrangement of loose/tight medullary sinuses and dense/thin medullary cords
Loose medullary sinuses and dense medullary cords
The cortex lobule of the thymus stains dark or light?
Dark
The medulla of thymus lobule stains dark or light?
Light
Double negative T cells enter cortex from __ and proliferate in __ area
From blood vessels, subcapsular area
Double positive T cells move to __ cortex
Outer
Single positive T cells move to __ cortex
Inner
Spleen filters…
Blood
Spleen converts hemoglobin to
Bilirubin
Spleen produces what 2 types of cells?
Lymphocytes and plasma cells
Spleen: T cells are found in the areas surrounding the central artery near the center of the white pulp. Forms the ___ sheath?
Pariarterial lymphatic sheath (PALS)
Spleen: Macrophages destroy worn-out or defective RBCs/WBCs?
RBCs
Spleen: Venous sinusoids are the storage site for healthy __ cells?
RBCs
Splenic artery enters __
Hilus
Spleen: After capillaries form, supplying white pulp, central arteries lose their white pulp investment and enter red pulp to form a ___
Penicillus
Spleen: Venous sinuses are line with ___ cells?
Reticuloendothelial cells
Consists of cells that typically pack areas of the lymphoid organ (mostly lymphocytes) describes…
Parenchyma
Consists mostly of reticular fibers and cells, including undifferentiated cells and fixed and free macrophages describes…
Stroma
Structure of a secondary lymph follicle contains a corona (cortex) and a germinal center. How do they stain?
Corona stain dark in its peripheral region and germinal center stains lighter
IgM produces what kind of lymphocytes?
B lymphocytes
MHC II is expressed where?
On the surface of B cels and antigen-presenting cells
MHC I helps in autoimmunity how?
Identifies self from foreign
CD4+ cells aka
Helper Cells
CD4+ recognize antigens bound to what MHC class molecules?
MHC II
CD8+ aka
Cytolytic T cells
CD8+ cells recognize antigens bound to what MHC class molecules?
MHC I
What is the site of lymphocyte reentry into lymph stream?
Medulla
Double negative T cells proliferate where?
Subcapsular area
Double positive T cells express what king of receptors?
BOTH CD4 and CD8 coreceptors and TCR receptors
What kind of receptors do single positive T cells express?
TCR receptors and EITHER CD4 or CD8 coreceptors
Billroth cords form red or white pulp parenchyma?
Red pulp
