IMMS Flashcards

1
Q

Mitochondria structure

A

double envelope membrane, folded into cristae (increase SA)

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2
Q

Which processes take place in mitochondria (and specifically where)

A
  • matrix, TCA cycle, link reaction and beta oxidation
  • outer mem, lipid synthesis and FA metabolism
  • inner mem, resp chain and ATP production
  • inner mem space, ADP->ATP phosphorylation
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3
Q

Types of endoplasmic reticulum and their function

A
  • rough ER, packages proteins
  • smooth ER, detox of hydrophobic molecules and mem lipid synthesis
  • sarcoplasmic R, stores and releases Ca2+
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4
Q

Golgi apparatus function

A

modification and packaging of proteins

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5
Q

Vesicle function

A

transport of proteins and enzymes

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6
Q

Peroxisomes function

A
  • consumes molecular oxygen
  • removes hydrogen from lipids, alcohol and toxic substances
  • produces H202 (can also destroy)
  • FA breakdown
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7
Q

Components of cytoskeleton

A

1) actin filaments (G & F actin)
2) intermediate filaments (nuclear laminin, keratin)
3) microtubules (tubulin)

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8
Q

Structure of cell membrane

A
  • phospholipid bilayer
  • cholesterol
  • proteins
  • sphingolipids
  • glycolipids
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9
Q

Function of cell membrane

A

1) barrier
2) detect chemical messengers arriving at cell surface
3) link adjacent cells
4) anchor cells to ECM
5) endo/exocytosis
6) allows AP to occur

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10
Q

Role of proteins in cell membrane

A

1) receptors to receive messages
2) protein channels to control cell content
3) maintains structural integrity
4) bind cell to ECM and anchor cells
5) AT pumps

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11
Q

What makes up cilia?

A

Tubulin and dyenin

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12
Q

Types of membrane proteins

A

1) G couples protein receptors (transduction pathways)
2) voltage gated channels (open at certain MP)
3) ligand gated channels (open when something binds to them)
4) mechanically gated channels (open when stretched)

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13
Q

Types of cell junction

A

1) tight, stop certain substances passing through
2) gap, allow passage of small molecules
3) desmosomes, allow degree of stretch (mainly structural not functional)

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14
Q

Types of movement across a cell membrane

A

1) diffusion
2) facilitated diffusion
3) primary AT
4) secondary AT (coupled)
5) exocytosis
6) endocytosis (basic, pinocytosis, receptor mediated)

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15
Q

glucose + glucose =

A

sucrose

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16
Q

galactose + glucose =

A

lactose

17
Q

fructose + glucose =

A

maltose

18
Q

what are the start and stop codons?

A
start = AUG
stop = UAA, UAG, UGA
19
Q

Define acid

A

proton donor

20
Q

define base

A

proton acceptor

21
Q

define buffer

A

weak acid with its conjugated base

22
Q

function of enzymes

A

biological catalysts

23
Q

function of co-enzymes

A

maximise action of enzymes functional groups

24
Q

Buffers in the body

A

1) Bicarb
2) Proteins in plasma, contain weak acid/base groups that can ‘mop up’ H+
3) haemoglobin, transports C02, 02 and buffers H+

25
Q

what is the anion gap?

A

difference between primary measured cations (+) and primary measured anions (-)

26
Q

define free radical

A

atom, molecule or ion with an unpaired electron

highly reactive and damaging to DNA

27
Q

examples of free radicals

A

1) OH (hydroxyl radical)
2) 02- (superoxide)
3) H202

28
Q

What is the benefit of ROS?

A

Respiratory burst, rapid release of oxygen species from cells (free radicals)

  • neutrophils use resp burst to break down bacterial cell walls during phagocytosis
  • rapid release of ROS from cells harms bacteria
29
Q

What are the damaging effects of ROS?

A
  • cellular damage

- damages membranes, nucleus and ER