Immediate And Induced Response

Question 1

PRR

Answer 1

Pattern recognition receptor

-detects PAMP’s

Question 2

PAMP’s

Answer 2

Pathogen-associated molecular pattern

Recognized immediately by
-macrophages
-dendritic cells
-mast cells
-epithelial cell (also express PRR’s)

Question 3

DAMP’s

Answer 3

Damage associated molecular patterns

Question 4

Toll-like receptors (TLR) :
Endosomal

Answer 4

Face the endosomal lumen, generally recognize intracellular pathogens

TLR-3,7,8,9

Question 5

Toll-like receptors (TLR) :
Extracellular

Answer 5

Face the extracellular environment, generally recognize extracellular pathogens

TLR-1,2,4,5,6

Question 6

TLR-4

Answer 6

Recognizes LPS (lipopolysaccharide)
-Gram negative

Requires accessory molecule MD2

Question 7

TLR-5

Answer 7

Recognizes flagellin

Question 8

NF-kB activation leads to:

Answer 8

-pro inflammatory cytokine and chemokine production
-adhesion molecule expression
(E-selectin if endothelial cell)

Question 9

IL1

Answer 9

Secreted by macrophages, neutrophils endothelial cells

Increase E selectin

Production of acute phase proteins in the liver. Induces fever

Question 10

E-selectin