Hematopoesis Flashcards
Hematopoietic stem cells (HSC)
2 types of differentiation
Asymmetrical : results in 1 stem cell & 1 progenitor cell
Symmetrical : results in either, 2 stem cells or 2 progenitor cells
Hematopoietic stem cell (HSC)
Transcription factor :
CD110 (C-Mpl)
Thrombopoietin : TPO
-self renewal
Hematopoietic stem cell (HSC)
Transcription factor :
CD117 (C-Kit)
Stem cell factor : SCF
-proliferation & differentiation
Hematopoietic stem cell (HSC)
Transcription factor :
CD105 (Endoglin), TGF-b
Transforming growth factor
-cell cycle dormancy
Hematopoietic stem cell (HSC)
Transcription factor :
CD202b (Tie2/Tek)
Angiopoietin-1 : Ang-1
-cell cycle Dormancy
Transcription factor (TF)
Sequence- specific DNA-binding factor
- a proteins that controls the rate of transcription by binding to a DNA sequence
Growth factor
Is a protein that stimulates cell growth
-they do not bind to a specific DNA
GM-CSF
Granulocyte macrophage colony stimulating factor
-granulocytes, monocytes , dendritic cells
G-CSF
Granulocytes and neutrophil colony stimulating factor
-neutrophils (PMN)
Erythropoietin
Is a growth factor secreted by the kidney
-stimulates marrow growth and red blood cell production
Regulated by hypoxia inducible factor (HIF) with detection of oxygen tension in the kidney
Transcription factor:
GATA2
Acute myeloid leukemia
- susceptibility to HIV
Transcription factor:
GATA1
Defective megakaryocyte maturation
Truncated GATA1 in males with Diamond- blackfan anemia
Transcription factor :
PU.1
Heterozygous deletion of PU.1 locus
Associated with acute myeloid leukemia
Transcription factor :
Core binding factor family -RUNX1
One of the most frequent chromosome translocations in acute myeloid leukemia
Erythropoiesis
Pluripotent stem cells evolve into red blood cells
It takes two weeks to make
And they can live 120 days
