IMM 2 Innate immunity

Question 1

Innate immunity functions and reactions?

Answer 1

Question 2

inflamation can result from what?

is it good?

what happens normally?

when its not normal?

Answer 2

Question 3

What causes infected area to be red and warm?

What causes swelling?

What do the immune cells do here?

what causes pain?

what other body reactoin?

Does innate responses work?

Answer 3

Question 4

Inflammation and infection steps

what doesnt inflammation work well against?

Answer 4

Question 5

What mediates the anti-viral response in the innate immune system.

Answer 5

Question 6

how do innate immune cells recognize self vs. nonself?

Answer 6

• innate immuknity have the ability to discriminate between self and nonself
• basic mechanism involves receptors which recognize “pathogen assoctiated molecular patterns”
• PAMPS
• cell receptor recognizing PAMPs are termed “pattern recognition receptors”
• PRRs

Question 7

what are the characteristics of PAMPs?

Answer 7

Question 8

Some examples of PAMPs?

Answer 8

Question 9

Properties of PRRs

Answer 9

Question 10

Mannose receptor

Answer 10

Question 11

Toll-like receptors

What are they what do they look for?

Answer 11

Question 12

which TLRs are extracellular? which are intracellular?

Answer 12

Question 13

Make chart of what TLRs combine or fight what?

Question 14

quick overview of the signalling pathway of TLRs

Answer 14

Question 15

Which TLRs for what type of foreign?

Answer 15

Question 16

Overall role of TLRs

Answer 16

Question 17

What does TLR activate in the end what do they cause?

what causes T-cell response?

Answer 17

Question 18

TLR-4 action

Answer 18

Question 19

What triggers inflammation?

Answer 19

PAMPs and DAMPs (damage associated molecular patterns)

Question 20

What causes DAMPs?

Answer 20

Question 21

What do DAMPs activate? what molecules do this?

Answer 21

Question 22

Nod-like receptors

Answer 22

Question 23

What do NLRs do specifically?

Answer 23

Question 24

Where are secreted forms of IL1beta and IL-18 produced?`

Answer 24

inflammasome

Question 25

Scavenger receptor family structure

is made up of what?

Answer 25

Question 26

functions of Scavenger receptors?

specifically talks about 2 SRs

Answer 26

Question 27

What are the receptors for carbohydrates?

What carbohydrates do they recognize?

why not humans?

two types?

Answer 27

Question 28

Functions of the Lectin receptor?

Answer 28

Question 29

Lectin and complement pathway?

Answer 29

Question 30

Epithelial barriers?

Answer 30

Question 31

What are defensins?

what produce them?

synthesis from what?

functions?

Answer 31

Question 32

What are Cathe’licidins

produced by what?

synthesis and stimed by?

fucntions?

Answer 32

Question 33

Anti microbial peptides functions

Answer 33

Question 34

what does innate immune system provide against microorganisms?

What cells are leukocytes?

which one is a Lymphocyte?

Answer 34

Question 35

function of different innate immune cells

Neutrophils?

macrophages?

eosinophils?

Natural killer cells?

Answer 35

Question 36

Maturation of mononuclear phagocytes

Answer 36