IMM 1 Introduction to the immune system Flashcards by Ross Larson | Brainscape

Q

Need for immune system?

(types of microbes)

A

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Q

Immune system comprised of what elements what are these element?

A

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Q

Different roles of the immune system in health and disease?

A

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Q

Herd immunity?

A

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Q

Active vs passive immunity?

A

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Q

Innate vs adaptive immunity?

A

Innate: first line of defense

gives rise to an acute inflammation

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Q

timeline for innate and adaptive immunity?

A

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Q

innate immune cells come from where?

A

Most are stationed in the blood and delivered into tissues on demand as a part of inflammatory responses or inflammation

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Q

immune cells in blood vs tissue?

A

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Q

origin of innate immune cells?

A

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Q

Polymorphonuclear granulocytes?

Mononuclear cells?

A

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Q

Cells that are Phagocytes?

Primary function?

A

Neutrophils and macrophages (monocytes)

primary function is to ingest and destroy microbes and get rid of damaged tissues (scavenger function)

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Q

steps in the functional responses of phagocytes

A

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Q

what can activated phagocytes do?

A

Secrete cytokines promote or regulate immune responses

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Q

What mediates the earliest phases of inflammatory reactions?

A

Neutrophils

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Q

Neutrophils in blood?

what are they produced in?

A

Bone marrow from precursors

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Q

What causes production of Neutrophils?

how many are made?

whats the difference between blood and tissues?

A

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Q

Mast cells, basophils and eosinophils?

A

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Q

Mast cells location?

A

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Q

Mononuclear phagocyte sytem?

A

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Q

what drives formation of macrophages?

A

monocyte/macrophage colony-stimulating factor

M-CSF

Q

route for monocyte/macrophage recruitment

A

Q

Macrophages functions

A

Q

dendritic cells

what type of immunity?

role?

A

Q

what type of dendritic cells are there?

A

Q

types of adaptive immunity?

what cells?

where do they develop?

what type of immunity does each cell participate in?

A

Q

cell-mediated immunity

defense against what?

interact with others?

A

Q

humoral adaptive immunity?

defense against what?

activate what?

A

Q

properties of adaptive immunity?

A

Q

adaptive immune cells lineage?

A

Q

generation of naive B cells

what are they?

where do they differentiate?

what causes development?

A

Q

GENERATION OF NAIVE T CELLS

types of T cells?

mature T cells go where?

A

Q

What helps in development of T cells and B cells?

A

B- contact with stromal cells and

Cytokines: IL-1 IL-6 IL-7

T- IL-1, IL-2, IL-6, and IL-7

Q

How does the immune system respond to a large number of different Ags?

A

Q

clonal selection

summary?

A

Q

humoral vs cell-mediated immunity

A

Q

classes of lymphocytes

A

Q

Antigen recoginition?

effector functions?

A

Q

A

Q

The cutaneous immune system.

What are the main cells here? what do they produce?

what is the main antigen presenting cell?

what pathway do these cells go under?

A

Q

The cutaneous immune system

where are CD4 and CD8 located here?

A

Q

Mucosal immune system.

Epithelium does what?

whats in the lamina propria?

what binds and neutralizes microbes here?

A

Q

Lymph nodes and where the T and B cells are located

as well as how they work

A

Q

The spleen structure and how it works along with T and B cell locations

A

Q

lymphocytes recirculation $

A

Q

lymphatic recirculation.

A

Q

migration of T lymphocytes

A

Q

migration of B lymphocytes

A

Q

A

Q

primary vs secondary adaptive immune response

A

Q

Immunologic memory

A