IMM 1 Introduction to the immune system

Question 1

Need for immune system?

(types of microbes)

Answer 1

Question 2

Immune system comprised of what elements what are these element?

Answer 2

Question 3

Different roles of the immune system in health and disease?

Answer 3

Question 4

Herd immunity?

Answer 4

Question 5

Active vs passive immunity?

Answer 5

Question 6

Innate vs adaptive immunity?

Answer 6

Innate: first line of defense

• gives rise to an acute inflammation

Question 7

timeline for innate and adaptive immunity?

Answer 7

Question 8

innate immune cells come from where?

Answer 8

Most are stationed in the blood and delivered into tissues on demand as a part of inflammatory responses or inflammation

Question 9

immune cells in blood vs tissue?

Answer 9

Question 10

origin of innate immune cells?

Answer 10

Question 11

Polymorphonuclear granulocytes?

Mononuclear cells?

Answer 11

Question 12

Cells that are Phagocytes?

Primary function?

Answer 12

Neutrophils and macrophages (monocytes)

primary function is to ingest and destroy microbes and get rid of damaged tissues (scavenger function)

Question 13

steps in the functional responses of phagocytes

Answer 13

Question 14

what can activated phagocytes do?

Answer 14

Secrete cytokines promote or regulate immune responses

Question 15

What mediates the earliest phases of inflammatory reactions?

Answer 15

Neutrophils

Question 16

Neutrophils in blood?

what are they produced in?

Answer 16

Bone marrow from precursors

Question 17

What causes production of Neutrophils?

how many are made?

whats the difference between blood and tissues?

Answer 17

Question 18

Mast cells, basophils and eosinophils?

Answer 18

Question 19

Mast cells location?

Answer 19

Question 20

Mononuclear phagocyte sytem?

Answer 20

Question 21

what drives formation of macrophages?

Answer 21

monocyte/macrophage colony-stimulating factor

M-CSF

Question 22

route for monocyte/macrophage recruitment

Answer 22

Question 23

Macrophages functions

Answer 23

Question 24

dendritic cells

what type of immunity?

role?

Answer 24

Question 25

what type of dendritic cells are there?

Answer 25

Question 26

types of adaptive immunity? what cells? where do they develop? what type of immunity does each cell participate in?

Answer 26

Question 27

cell-mediated immunity defense against what? interact with others?

Answer 27

Question 28

humoral adaptive immunity? defense against what? activate what?

Answer 28

Question 29

properties of adaptive immunity?

Answer 29

Question 30

adaptive immune cells lineage?

Answer 30

Question 31

generation of naive B cells what are they? where do they differentiate? what causes development?

Answer 31

Question 32

GENERATION OF NAIVE T CELLS types of T cells? mature T cells go where?

Answer 32

Question 33

What helps in development of T cells and B cells?

Answer 33

B- contact with stromal cells and Cytokines: IL-1 IL-6 IL-7 T- IL-1, IL-2, IL-6, and IL-7

Question 34

How does the immune system respond to a large number of different Ags?

Answer 34

Question 35

clonal selection summary?

Answer 35

Question 36

humoral vs cell-mediated immunity

Answer 36

Question 37

classes of lymphocytes

Answer 37

Question 38

Antigen recoginition? effector functions?

Answer 38

Question 39

Answer 39

Question 40

The cutaneous immune system. What are the main cells here? what do they produce? what is the main antigen presenting cell? what pathway do these cells go under?

Answer 40

Question 41

The cutaneous immune system where are CD4 and CD8 located here?

Answer 41

Question 42

Mucosal immune system. Epithelium does what? whats in the lamina propria? what binds and neutralizes microbes here?

Answer 42

Question 43

Lymph nodes and where the T and B cells are located as well as how they work

Answer 43

Question 44

The spleen structure and how it works along with T and B cell locations

Answer 44

Question 45

lymphocytes recirculation $

Answer 45

Question 46

lymphatic recirculation.

Answer 46

Question 47

migration of T lymphocytes

Answer 47

Question 48

migration of B lymphocytes

Answer 48

Question 49

Question 50

primary vs secondary adaptive immune response

Answer 50

Question 51

Immunologic memory

Answer 51