IM ortho/rheum Flashcards
autoimmune disease causing vascular damage and excess production and deposition of collagen in the extracellular matrix of the skin
scleroderma (systemic sclerosis)
Skin tightening around the fingers with pitting at the fingertips
scleroderma
CREST
Calcinosis of the skin
Raynaud phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasia
Labs for scleroderma
anti-topoisomerase I (anti-Scl-70) antibody (specific for diffuse disease)
anti-centromere antibody (specific for limited disease)
tx for scleroderma
supportive
CCB for Raynauds
general manifestations of scleroderma
fatigue
stiff joints
loss of strength
pain
sleep difficulties
skin discoloration
Patient with a history of lupus or other rheumatic diseases
Complaining of repeated spontaneous abortions
Labs will show thrombocytopenia
Most commonly caused by autoimmune
Treatment is anti-coagulation
antiphospholipid syndrome
hypoparathyroidism
low PTH = low Ca
signs of hypocalcemia seen upon hypoparathyroidism
tetany
chvostek sign
trousseau sign
paresthesias (fingertips, perioral)
prolonged QT interval
chvostek sign
hypoparathyroidism
contraction of facial muscles after tapping facial nerve
Trousseau sign
induction of carpal pedal spasm
hypoparathyroidism labs
Labs will show low PTH, low calcium, high phosphorus
Patient will be a woman 40 - 50-years-old
Complaining of morning stiffness lasting > 30 minutes
PE will show symmetrical soft, red, tender, swelling in joints -MCP, PIP. Bilateral ulnar deviation at MCP, boutonniere deformity, and swan-neck deformity
Labs will show positive RF, anti-cyclic citrullinated peptide antibodies
Most commonly caused by autoimmune destruction of synovial joints
Treatment is DMARDs
RA
what does PE of RA show?
symmetrical soft, red, tender, swelling in joints -MCP, PIP.
Bilateral ulnar deviation at MCP, boutonniere deformity, and swan-neck deformity
Dx of RA
Labs will show positive RF, anti-cyclic citrullinated peptide antibodies
