IM 2 Flashcards
compare CML to LR
LR has HIGH alk phsophatase score, greater proption fo late neutrophil precursors, lack of absolute basophilia
tx of hepatic encephalopathy
lactulose
AMS, nystagmus and ataxia in alcoholic
thiamine deficiency with wernicke encephalopathy
why glucagon in tx of BB or CCB OD
incrased cAMP, corrects refractory hypotension if pt doesn’t initially respond to atropine and fluid boluses
phenytoin toxicity
horizontal nystagmus, ataxia, N/V, AMS
old person on a medication with recent addition and now new sx
think medication interaction
isolated thyrombocytopneai, mucocutaneous bleeding, easy bruising, IgG autoantibodies against platelet membrane glycoproteins
ITP
ADAMTS13
TTP = thrombocytopenia + MAHA
degeneration of GABA producing neurons in caudate nucleus and putamen
HD
rectangular, envelope-shaped calcium oxalated crystals in pt with AMS
eythlene glucol poisoning
pt presents with concern of dropping left face. how to differentiate peripheral vs central nerve lesions?
central = upper facial muscles are spared due to compensation from the unaffected hemisphere peripheral = bell palsy = weakness of the entire half of the face
screening and dx test for MM
screen = serum or urine protein electrophoresis, free light chain analysis diagnosis = BM biopsy
following MI, develops sx of HF, refractory angina, ventricul arrythmias, functional MR, mural thrombus and ECT shows persistent ST elevation and deep Q waves
ventricular aneurysm, late MI complication
presentation of MR after MI
due to papillary muscle rupture, 2-7 days post MI, presents dramatically with acute, severe MR (hypotension, pulmonary edema, cardiogenic shock)
what are untreated hyperthyroid pts at risk of?
rapid bone loss from increased osteoclastic activity, cardiac tachyarrhythmias, including afib
microcytic anemia, HTN, neprhopathy, hyperuricemia, basophillic stippling on peripher smear
lead toxicity, tx is EDTA chelation
anti-TPO antibodies
Hashimoto’s thyroiditis; also associated with increased risk of miscarriage
anti-mitochondrial Ab
primary biliary cholangitis
phenytoin can lead to megaloblastic anemia and gingival hyperplasia due to impaired absorption of _____
folic acid
vitamin B1
thiamine
HIV pt with severely advanced disease (CD4<100) and lung symptoms
progressive disseminated histoplasmosis; get urine or serum histoplasma antigen assay
fevers, chills, malaise, weight loss, cough, dypsnea, mucocutaneous lesions, LAD in pt with HIV
disseminated histoplasmosis; tx is amphotericin
HTN, mild hypernatremia, metabolic alkalosis, suppressed plasma renin activity
primary hyperaldosteronism
how to distinguish benzos from opioid OD
benzo = lack of severe respiratory depression and pupillary constriciton
leaning on elbows, decreased sensation over the 4th and 5th fingers, weak grip
ulnar entrapment
antiGBM
goodpasture’s syndrome
hemolysis (elevated bili and LDH), cytopenias, hypercoagulable state (venous thrombosis), flow cytometry with absence of CD55 and CD59
paroxysmal noctural hemoglobinuria
____ is an impt cause of RHF, characterized by progressive peripheral edema, scites, elevated JVP, pericardia knock, and pericardial calcifications
constrictive pericarditis