III - Topnotch Pharma Flash Cards - Drugs for Smooth Muscles
more likely to block autonomic receptors, also has alpha1 blocking and local anesthetic effect
1st Generation antihistamines (TOPNOTCH)
Reversible blockade of histamine H1-receptor sites on tissues, No sedation and antimuscarinic effects
2nd Generation antihistamines (TOPNOTCH)
may cause arrhythmia due to blockade of cardiac potassium channels
acrivastine, astemizole, cetirizine, loratadine, and terfenadine (TOPNOTCH)
reduction of nocturnal acid secretion in gastirc and duodenal ulcer
H2 antagonists (TOPNOTCH)
True or False: H2 antagonists have H1-blocking effect
FALSE (TOPNOTCH)
True or False: Ranitidine is a CYP450 inhibitor
TRUE, but weak inhibitor only (TOPNOTCH)
Agonist at the 5HT1D receptor in the blood vessels causing vasocontriction ; 1st line treatment for Acute migraine and cluster headache attacks
5HT1D receptor agonist: Sumatriptan, Naratriptan, Almotriptan, Eletriptan, Frovatriptan, Rizatriptan, Zolmitriptan (TOPNOTCH)
Selectively block 5HT3 receptors ; For antiemesis in patients post-chemotherapy or post-operation
5HT3 receptor antagonist: Ondansetron, Granisetron, Dolasetron, Alosetron (TOPNOTCH)
can inc QRS and QT (proarrhythmic effect) duration so never use in patients with heart disease
Dolasetron (TOPNOTCH)
SE: gangrene (sec to Ischemia) in overdose, unusual hyperplasia of the retroperitoneal, retropleural or subendocardial cavity –> hydronephrosis, cardiac valvular and conduction system malfunction
Ergotamine (TOPNOTCH)
uterus becomes more sensitive to ergots during pregnancy, produce very powerful and long-lasting contraction leading to decreased bleeding, Never give before delivery of placenta
Ergonovine (TOPNOTCH)
PGE1 analogue, causes increased HCO3 and mucus secretion in stomach and uterine contraction
Misoprostol, Gemeprost (TOPNOTCH)
may also be used together with Mifepristone or Methotrexate as safe abortifacient
Misoprostol (TOPNOTCH)
Low concentrations contract, higher concentrations relax uterine and cervical smooth muscle, soften cervix at term before induction with oxytocin
Dinoprostone, Sulprostone (TOPNOTCH)
PGF2a analogue, increases outflow of aqueous humor thus reduces intraocular pressure; For glaucoma
Prostaglandin F2a analog: Latanoprost, Arboprost, Bimatoprost, Travoprost, Unoprostone (TOPNOTCH)