VI - Topnotch Pharma Flash Cards - Endocrine Drugs
Recombinant Growth hormone
Somatropin (TOPNOTCH)
Increases release of IGF-1 in the liver and carilage, stimulates skeletal muscle growth, amino acid transport, protein synthesis and cell proliferation
Somatropin (TOPNOTCH)
Recombinant IGF-1
Mecasermin (TOPNOTCH)
Somatostatin analog
Octreotide, Lanreotide (TOPNOTCH)
suppresses the release of growth hormones, glucagon, insulin, gastrin, IGF-1, serotonin and gastrointestinal peptides
Octreotide, Lanreotide (TOPNOTCH)
For Acromegaly, pituitary adenoma, carcinoid, gastrinoma, glucagonoma, variceal bleeding
Octreotide, Lanreotide (TOPNOTCH)
GH receptor antagonist ; For acromegaly
Pegvisomant (TOPNOTCH)
Gonadotropin analog (FSH analog) ; For Controlled ovarian hyperstimulation, infertility due to hypogonadism in men
Follitropin alfa, Follitropin beta, Urofollitropin (TOPNOTCH)
Gonadotropin analog (LH analog)
For Controlled ovarian hyperstimulation (ovulation induction), hypogonadotripic hypogonadism (TOPNOTCH)
SE: Headache, depression, edema, ovarian hyperstimulation syndrome, multiple pregnancies in women, gynecomastia in men
FHS and LH analogs (TOPNOTCH)
GnRH analog
Leuprolide, Gonadorelin, Goserelin, Histrelin, Nafarelin, Triptorelin (TOPNOTCH)
For Controlled ovarian hyperstimulation, endometriosis, myoma uteri, precocious puberty, postate CA
Leuprolide, Gonadorelin, Goserelin, Histrelin, Nafarelin, Triptorelin (TOPNOTCH)
there is exacerbation of symptoms in males with prostate CA and children with precocious puberty during the first few weeks of therapy
GnRH analog (TOPNOTCH)
For GnRH analogs: increased LH and FSH secretion with ________ administration , reduced LH and FSH secretion with ________ administration
intermittent ; prolonged continuous (TOPNOTCH)
GnRH antagonist
Ganirelix, Cetrorelix, Degarelix (TOPNOTCH)
For Controlled ovarian hyperstimulation (prevents premature LH surge), advanced prostate CA
Ganirelix, Cetrorelix, Degarelix (TOPNOTCH)
Does NOT cause tumor flare-up whe used for treatment of advanced prostate cancer
Ganirelix, Cetrorelix, Degarelix (TOPNOTCH)
_____ is used for prostate CA while _____ prevent LH surge in controlled ovulation
Degarelix ; Ganirelix (TOPNOTCH)
Dopamine agonist, partial agonist at dopamine D2 receptors in brain ; For Hyperprolactinemia, Pituitary adenoma, acromegaly, Parkinson’s disease
Bromocriptine, Carbegoline (TOPNOTCH)
Activates oxytocin receptors stimulates uterine contraction and labor, stimulates mammary glands, lactation and milk let-down
Oxytocin (TOPNOTCH)
For Labor induction, labor augmentation, control of uterine hemorrhage post-delivery
Oxytocin (TOPNOTCH)
oxytocin antagonist used in preterm labor
ATOSIBAN (TOPNOTCH)
ADH agonist, Vasopressin V2 receptor agonist
Desmopressin (TOPNOTCH)
For Central DI, Hemphilia A, von Willebrand’s disease, Variceal bleeding, primary nocturnal seizures
Desmopressin (TOPNOTCH)
SE: Fetal distress, placental abruption, uterine rupture, fluid retention, hyponatremia, heart failure, seizures, hypotension
Oxytocin (TOPNOTCH)
ADH antagonist, Antagonist at V1a and V2 receptors
Conivaptan, Tolvaptan (TOPNOTCH)
_____ may occur with rapid correction of hyponatremia
Central pontine myelinolysis (TOPNOTCH)
Which is more selective for V2 receptors, Conivaptan or Tolvaptan?
tolvaptan (TOPNOTCH)
Thryoid hormone ; For Hypothyroidism, myxedema coma
Levothyroxine (T4), Liothyronine (T3) (TOPNOTCH)
T or F: Liothyronine has a faster onset but shorter half-life
TRUE (TOPNOTCH)
Inhibits thyroid peroxidase reactions, blocks iodine organification, inhibits peripheral conversion of T4 into T3
Propylthiouracil (PTU) (TOPNOTCH)
Drug of choice for pregnant hyperthyroid patients
Propylthiouracil (PTU) (TOPNOTCH)
Inhibits thyroid peroxidase reactions, blocks iodine organification
Methimazole, Carbimazole (TOPNOTCH)
Inhibit iodine organification and hormone release leading to reduced size and vascularity of thyroid gland
Lugol Solution (Iodine in Potssium Iodide), Potassium Iodide (TOPNOTCH)
onset is more rapid (2-7 days) but effect is transient ; Should not be used alone (escape in 2-8 weeks); prevents radiation induced thryoid damage; prenatal exposure causes fetal goiter
Lugol Solution (Iodine in Potssium Iodide), Potassium Iodide (TOPNOTCH)
Beta blocker control HR and other cardiac abnormalities of severe thyrotoxicosis, slows pacemaker activity; inhibits peripheral conversion of T4 into T3
Propranolol, Esmolol, Metoprolol, Atenolol (TOPNOTCH)
_____ may be used to treat thyrotoxicosis-related arrhythmias
Esmolol (TOPNOTCH)
Iodide, emits beta rays causing destruction of thyroid parenchyma
Radioactive Iodine (TOPNOTCH)
For hyperthyroidism, permanent cure of thyrotoxicosis without surgery and no effect on other tissues
Radioactive Iodine (TOPNOTCH)
Preferred treatment for most patients due to ease of administration, effectiveness, low expense and absence of pain; contraindicated in pregnant women or nursing mothers
Radioactive Iodine (TOPNOTCH)
Low Potency Glucocorticoid (GC)
Desonide (TOPNOTCH)
Medium Potency GC
Fluticasone, Mometasone (TOPNOTCH)
High Potency GC
Desoximetasone, Clobetasol (TOPNOTCH)
Effects: stimulate gluconeogenesis, increased fat deposition, protein catabolism, inhibit cell-mediated immunologic functions, lymphotoxic, increased neutrophils, decreased lymphocytes, eosinpphils, basophils and monocytes, inhibit leukocyte migration, inhibit PLA2
Glucocorticoids (TOPNOTCH)