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Fall P2 > IDT - Antipsychotics Filtz > Flashcards

IDT - Antipsychotics Filtz Flashcards

1
Q

Mental Disorder characterized by rifts in rational thought, inappropriate processing of sensory info, and disturbed views of reality and self. Not recognized by the sufferer

A

Psychoses

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2
Q

Abnormal reaction to an external state that is generally recognized as abnormal by the sufferer

A

Neuroses

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3
Q

Psychotic Markers

(Positive) Over Symptoms

A 
Delusions
Paranoia
Hallucinations (auditory > visual)
Disordered thoughts
Loose Ideation
Innappropriate Emotional Responses
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4
Q

Association of a color/temperature/etc with a visual, taste or smell perceptions

A

Synesthesia

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5
Q

In what disease states is Psychoses often seen?

A 
Schizophrenia
Delirium (dementia)
Manic Psychoses
Secondary to severe depression
Post-Traumatic stress disorders
Drug-induced
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6
Q

What type of responses are often seen in Psychoses patients?

A 
Lashing out (verbally)
(less common) Violences in response to fear
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7
Q

What Drugs may induce a psychoses or psychotic symptoms?

A 
Amphetamine
Steroids
LSD
Ketamine
PCP
Sedative/Hypnotics
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8
Q

Why do Dementia patients often experience psychotic symptoms?

A

Delirium causes cognitive decline which may lead to hallucinations and delirium

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9
Q

Why might PTSD display psychotic symptoms?

A

Auditory hallucinations, etc, misinterpreting stimuli

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10
Q

What is the age of onset of Schizophrenia?

A

15-25 yo

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11
Q

What percentage of the population experience schizophrenia psychotic symptoms? What groups affected most?

A

~1% of the population

women and men affected equally

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12
Q

What is the mortality rate/prognosis of schizophrenia?

A

10%, poor long term prognosis

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13
Q

What type of behavior often precedes onset of psychoses?

A

“odd” behaviors

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14
Q

What are “negative” (residual symptoms) of schizophrenia?

A

Flat affect (same expression)
Anhedonia/Apathy (no care)
Anxiety
Lack of volition
Social and emotional withdraw (being called crazy)
Disorganized speech, thinking and behavior
Impaired attention (due to inner dialogue)
Poor Self-care

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15
Q

What is common Etiology of Schizophrenia?

A

Neurodevelopmental Disorders
Genetic Factors
Environmental Factors

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16
Q

What study showed that there are genetic and environmental factors in causation of schizophrenia?

A

Twin studies in monozygotic twins, which looked at anatomic irregularities where only one twin was affected by schizphrenia

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17
Q

What anatomic Irregularities can be seen in schizophrenic patients’ brains?

A

Enlarged Cerebral Ventricles
Reduced Cortical Mass
Hypofrontality (reduced processing in the prefrontal cortex)

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18
Q

What Treatment was often used in the 1940’s and 1950’s for psychoses expressing patients?

A

Frontal Lobotomy, separated prefrontal cortex, which drastically calmed patients, but permanently debilitated them by placing them in a zombie like state.

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19
Q

What Treatment options currently exist for those experiencing psychosis?

A
  • Frontal Lobotomy (not ethical)
  • Psychotherapy
  • Cognitive Behavioral Therapy (no psychoses)
  • Self-medication w/ Nicotine
  • Antipsychotics
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20
Q

When might Cognitive Behavioral therapy be useful?

A

Teaching patients –>
Social skills
Life skills (attendance, housing)
Ability to self-assess

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21
Q

What percentage of psychoses patients self medicate with nicotine?

A

90%

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22
Q

What is the primary effect of Antipsychotic Agents

A

Neuroleptics, Major Tranquilizers

Treat by calming psychotic symptoms
less effect on emotional or social problems

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23
Q

What percentage of individuals do Antipsychotic medications help effectively?

A

70% Respond eventually

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24
Q

What else can Antipsychotic agents be used for?

A

Supplementation with Anesthesia

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25
What is the latency of effectiveness in Antipsychotic agents?
Calming (tranquilizing) effect may be seen within minutes to hours Diminshed psychotic symptoms seen within 24-28 hrs
26
How long until full antipscyhotics effects evolve?
2-8 wks
27
How long may improvements from antipsychotics continue and what symptoms resolve?
6 months - fewer hallucinations - Less paranoia - More rational thinking
28
What is the action of ALL antipsychotic drugs?
D2 receptor antagonism
29
For the D2 Receptor Agonist drugs concentration to clinical dose curve, what is the most potent drug?
Spiroperidol
30
What Dopamingergic pathways may be changed by antipsychotics?
Mesocortical Mesolimbic Nigrostriatal Tuberinfundibular
31
Where is the Mesocortical pathway?
Ventral Tegmental Area to frontal and prefrontal cortex, pathway responsible for reasoning (loose ideation when compromised)
32
Where is the Mesolimbic pathway?
Ventral Tegmental Area to N. Accumbens in limbic area | Pathway responsible for emotional response (social withdrawal and agitation when compromised)
33
Where is the Nigrostriatal pathway?
Substantia Nigra to Striatum (More EPS side effects with D2 antagonism)
34
Where is the Tuberoinfudibular pathway?
Hypothalamus to pituitary (Prolactin side effects with D2 antagonism)
35
What is the Dopamine Theory of Psychosis?
That Psychoses results from over-stimulated dopamine receptors in the cortex (reasoning) and limbic (emotional) areas.
36
What is Dopamine Hypofrontality?
A hypothesized lack of dopamine within the mesocortical pathway that leads to decreased cerebral blood flow
37
What is the explanation of "positive" psychoses symptoms?
Dopamine hyperactivity of mesolimbic that inhibits mesocortical pathway
38
What is the role of Serotonin signaling in psychosis?
Some antipsychotics have affinity with 5-HT2 receptors "Negative" symptoms associated with Serotonin dysfunction
39
What is the role of Glutamate signaling in psychosis?
Glutamate antagonists act at NMDA receptors to exacerbate or produce psychoses
40
What drug is known as the "grandparent" of all antipsychotics
Chlorpromazine
41
First Gen Phenothiazines or Thioxanthines
Chlorpromazine Thioridazine Fluphenazine Thiothixene
42
What are and what is the advantage Butyrophenones?
Haloperidol; Pimozide | More D2 selective
43
2nd Generation Dibenzazepine antipsychotics
Clozapine Loxapine Olanzapine Quetiapine
44
What are the side effects of blocking Dopamine in the Nigrostriatal pathway?
- Problems with initiation and control of movement/muscle tone - Antagonism of D2 receptors in BG (EPS)
45
What are the Acute Extrapyramidal side effects (EPS) of D2 antagonism?
``` Akathisia (motor restlessness) Dystonia Respiratory Distress Pseudo-Parkinsonism - bradykinesia - resting tremor - flat affect ```
46
How do EPS and Dose changes affect individuals?
See more EPS with high dose bolus. | Decreasing dose, changing drugs and adding anti-Parkinson agents may help EPS
47
Who are more likely to experience EPS?
Women are more sensitive than men.
48
What can EPS lead to?
Irreversible Tardive dyskinesias (involuntary movements of tongue, lips, head and neck)
49
What type of drugs can be used to reduce EPS?
Muscarinic receptor agonists are inversely correlated with EPS
50
In general, which generation of antipsychotics cause less EPS?
2nd Gen
51
How might you treat Tardive Dyskinesia?
Withdrawal or reduction in dose of antipsychotic medications Administration of a-colinomimetic Vitamin B6 supplementation
52
What normally inhibits Pituitary D2 receptors?
Prolactin - prolactin levels > 100 ng/ml prolactinomas, increase risk of breast cancer
53
When there is a blockade of D2 inhibition there is?
An increased prolactin release - gynecomastia and increased lactation - disturbed thermal regulation (hypo/hyperthermia) - Amennorhea (weird menstruation), infertility and sexual dysfunction
54
When prolactin levels > 100 ng/ml or more
Prolactinomas increases the risk of breast cancer
55
On average 2nd generation Antipsychotics have higher?
Affinity for 5-HT2 receptors - have somewhat lower affinity for D2 dopamine receptor - generally, have lower incidence of EPS and endocrine side effects
56
What is recommended as first line therapies for Antipsychotics?
2nd generation antipsychotics | - have other side effects
57
Where is the Serotonergic CNS pathways projected from and to?
``` From the dorsal raphe nuclei in brainstem to: pre-frontal cortex Hypothalamus Limbic areas Spinal Reflex areas Basal Ganglia ```
58
Where is the Serotonergic CNS pathways projected to?
pre-frontal cortex, hypothalamus, limbic area, spinal reflex areas and basal ganglia
59
What does the 5HT2 receptors modulate?
Dopamine
60
Why are there fewer EPS with antipsychotics that combine 5-HT2 antagonism
there is lower affinity D2 antagonism due to 5-HT modulation
61
When there is lower affinity D2 antagonism and more 5HT2 antagonism...
5-HT modifies dopamine release in the basal ganglia
62
What Autonomic Effects can be seen from use with antipsychotics?
alpha 1 adrenergic antagonism | muscarinic cholinergic antagonism (inc temp, dry skin, cant see, flushing, unstable mood)
63
What can Histamine H1 antagonism lead to?
Sedation Drowsiness Weight gain Anti-Nausea
64
When might sedation therapy be difficult or useful in psychoses patients?
Difficult --> Patients on prophylactic or chronic therapy, where condition is well controlled. Useful --> Acute treatment of florid psychoses w/ agitation
65
Why is weight gain/metabolic disorder seen with antipsychoses patients?
Serotonin, H1 histamine and alpha 1 adrenergic receptors are blocked
66
What is the result of blockage of serotonin, H1 histamine and alpha 1 adrenergic receptors on metabolism?
``` Increased appetite Inc Fat storage Sleep Apnea Hypercholesterolemia Insulin insensitivity and hyperglycemia ```
67
What antipsychotics are associated with large weight gains?
Clozapine, Olanzapine, Chlorpromazine and Thioridazine
68
What APs are associated with moderate weight gains?
Risperidone, Quetiapine, Paliperidone, Iloperidone
69
What APs are seen as weight neutral?
Ziprasidone, Aripiprazole, Haloperidol, Asenapine
70
Which APs may cause a large increased risk of sudden cardiac death by prolonged QT intervals?
Ziprasidone, pimozide, Thioridazine
71
What levels should be monitored in patients on antipsychotic therapy?
Lipids Weight HbA1c Blood Pressure
72
What potential fatal cardiotoxicities are exacerbated with use of antipsychotics?
Increased QT interval, (Torsades de Pointe) Black box warning on Antipsychotics
73
Which patient population is on the black box warning for antipsychotic agents?
Dementia Patients, elderly | drastically increased mortality rates
74
What is Neuroletpic Malignant syndrome?
A rare syndrome that recurs w/ 10% mortality rate in patients with severe EPS
75
What are the symptoms of Malignant Syndrome?
Manifestations of Hyperthermia and Diaphoresis (sweating) Altered Mental Status Tremors/Muscle rigidity Acute Renal Failure
76
What is the treatment for Maligant Syndrome?
Discontinuation of Antipsychotic medications (patient untreatable) Dantrolene or Bromocriptine
77
Where do the majority of Hypersensitivity reactions in antipsychotics occur?
Phenothiazines Dermal Reactions (rash and photosensitivity) Asenapine (serious hypersensitivity/anaphylaxis)
78
What is Clonidine?
an Alpha 2 agonist (review for P3 year)
79
Advantages, Toxicities and features of Clozapine?
Uniquely effective in 25-30% of treatment-resistant patients (No EPS) Serious Toxicity!! - Leukopenia (required WBCs) - Myocarditis (heart inflammation) - Cardiovascular Collapse (BP crashes) - Decreased Seizure threshold May cause sedation/antimuscarinic effects (constipation)
80
Advantages, Toxcities, and features of Olanzapine?
No toxicities of Clozapine 2nd most effective of antipsychotics (not as good as Clozapine) Weight gain is VERY problematic
81
Advantages and use of Quetiapine?
Very Sedating (anxiolytic) Low EPS Low adrenergic blockage Moderate weight gain/Risk of metabolic syndrome
82
Risperidone Pros and Cons?
+ Lack of sedations - restlessness/agitation - dose needs to be controlled to avoid EPS + approved for irritability in autism spectrum disorders (5yo+)
83
Paliperidone Pros and Cons?
+ Lack of sedation + Sustained release, once monthly dosing - Restlessness/agitation - EPS
84
Ziprasidone/Lurasidone Pros and Cons?
+ low weight gain + Low EPS - Problems with QT prolongation (Lurasidone less)
85
Iloperidone Pros and Cons
``` + Low EPS + Low anti-cholinergic + low weight gain + low tendency for Metabolic Syndrome - Hypotension (alpha 1 antagonism) - Requires dose tiration ```
86
Asenapine Pros and Cons
``` + Minimal weight gain or metabolic disturbance + Off label to treat PTSD - Extreme Sedation - Serious Hypersensitivity - EPS - Not very efficacious ```
87
Aripiprazole Pros and Cons
``` + Good Efficacy + partial D2 agonist + No receptor Sensitization + No endocrine disturbances + Low EPS - transient Nausea - Agitating - alpha 1 antagonism ```
88
Brexipiprazole Pros and Cons
``` + partial D2 agonist + low risk EPS - alpha 1 antagonism + low affinity for histamine receptors - weigh gain, akathesia as side effects ```
89
Cariprazine Factoids
+ D2 partial agonist, 5HT1a Partial agonist, 5HT2 antagonist + Low EPS + low weight gain - D3 partial agonist with higher affinity for D3R than D2R
90
APA top 5 recommendatons for choosing wisely
1) don't prescribe APs without appropriate initial evaluation and ongoing monitoring 2) No routine prescribing 2 or more APs 3) No Aps as first choice for behavioral and psychological symptoms of dementia 4) No routine prescription of APs as first line intervention for insomnia 5) No routine prescription as first line intervention for children or adolescents for anything other than psychotic disorders
91
What other indications are APs used for?
``` Tourette's Neuroletanesthesia Antidpressants (no monotherapy) Behavioral problems Bipolar disorder Severe Nausea/Vomitting Intractable hiccups Insufficient lactation ```

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