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Hematology > Identification > Flashcards

Identification Flashcards

1
Q

Variation in shapes of RBC

A

Poikilocytosis

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2
Q

Variation in sizes of RBC

A

Anisocytosis

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3
Q

Leukoerythroblastosis is not associated with ______

A

Erythroblastosis fetalis (HDN)

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4
Q

Procedure employs blood w/ EDTA diluted with 0.105 M NaCitrate or NSS

A

Modified Westergren

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5
Q

What is the T-cell growth factor and mast cell activating factor effect in stimulating erythroid and myeloid proliferation

A

Interleukin-9 or IL-9

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6
Q

Largest of all hematopoietic stem cells

A

Polypoid megakaryocyte

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7
Q

Which among RBC has figure of 8, loop shape

A

Cabot ring

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8
Q

Which among cells is the earliest erythroid recognizable precursor

A

Pronormoblast

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9
Q

Which of the ff mononuclear cells are w/o specific cytoplasmic granules

A

Lynphocytes

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10
Q

Which ff cell is larger than monocyte w/ irregular cell membrane with blunts and pseudopods

A

Megakaryoblast

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11
Q

Common precursor for granulocytes, monocytes, erythrocytes and megakaryocytes

A

Myeloid stem cells

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12
Q

Rbc thinner than normal, peripheral rim of hemoglobin w/ dark Hgb containing area

A

Leptocytes

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13
Q

Disintegrating RBC

A

Leptocytes

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14
Q

Cell that has deep purple and paler nucleus which often nearly hidden by granules

A

Basophils

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15
Q

Last nucleated cell

A

Orthochromic normoblast

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16
Q

Hematopoietic stem cells also known as CFU-GEM expresses

A

CD34/CD33

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17
Q

Large cell w/ single eccentric nucleus has reticular chromatin and prominent nucleolus

A

Osteoblast

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18
Q

Promotes differentiation and maturation of
megakaryocytes

A

Thrombopoietin

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19
Q

Nutritional deficiency of Cobalamine, due to failure of gastric mucosa produce intrinsic factors

A

Pernicious anemia

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20
Q

During fetal life, all Rbc produce HbF, in adults, 0.2-7% are HbF

A

True

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21
Q

Reticulocytopenia and ABN RBC are primary findings, ABN granulocyte are rare and less than 1% blast cells

A

Refractory anemia

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22
Q

Acute myelocytic leukemia seen in

A

M4

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23
Q

Earliest Thrombopoiesis w/ overlapping lobe and small amount of basophilic cytoplasm

A

Megakaryoblast

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24
Q

Degrades fibrin clot and retract fibrinogen forms FDP

A

Plasmin

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25
Q

Content of eosinophilic specific granules toxic to parasite that neutralize heparin and release histamine

A

Major basic protein

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26
Q

Autosomal dominant that failure normal segmentation of neutrophils:

A

Pelger-huet anomaly

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27
Q

AML w/ minimal differentiation

A

M0

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28
Q

A molecule of Hgb is consist of ___ polypeptide chain

A

2

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29
Q

A mixture of oxidized denatured Hgb during oxidative hemolysis

A

Sulfhemoglobin

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30
Q

Principle involved in automated counting

A

Electric impedance

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31
Q

Measures fibrin clot from activation of F7 to fibrin stabilizing clot:

A

PT

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32
Q

Measures fibrin clot from activation of F7 to fibrin stabilizing clot:

A

Myocosis fungoides

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33
Q

Global test adequacy of primary hemostasis

A

Template bt

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34
Q

Activator that initiates the fibrinolysis and convert plasminogen to plasmin -

A

t-PA

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35
Q

Primary test in diagnosis of hairy cell leukemia

A

ACP

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36
Q

Decrease function of F2, 7, 10 (Protein C, Protein S)

A

Warfarin

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37
Q

Prolonged pt and normal ptt seen in patients with deficiencies in which factor in intrinsic factor

A

8,9,11,12

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38
Q

Prolonged pt and normal ptt seen in patients with deficiencies in which factor in extrinsic factor

A

7

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39
Q

Cofactor of required in activation of F2 by activated F8

A

5

40
Q

Diluting fluid in platelet count in phase contrast

A

1%NH4Oxalate

41
Q

In phase contrast microscope, how many squares in platelets in improved neubauer

A

25 small squares

42
Q

Light angle scatter in laser-based cell counting chamber is used to measure

A

cytoplasmic granularity

43
Q

Patients with infectious mononucleosis, this blood cell is infected

A

B-lymphocyte

44
Q

Inhibits factor 2,9,7,11,10, enhances the activity of anti- thrombin as natural anticoagulant

A

Heparin

45
Q

Which of the ff not function of spleen as hematopoietic origin

A

Secretion of mitogen

46
Q

Immature non-nucleated RBC with RNA granules

A

Reticulocytes

47
Q

Not associated with sickle cell

A

Promotes spleen destruction

48
Q

Tissue extract with phospholipid and tissue factor that activates F7 in extrinsic pathway

A

Thromboplastin

49
Q

An 18- Kda produce by activated T-cell and mast cell

A

IL-4

50
Q

General measure in extrinsic and common pathway

A

PT

51
Q

General measure in intrinsic and common pathway

A

PTT

52
Q

Condition of panmyelosis with increase megakaryocytes, granulocytes, erythrocytes

A

Polycythemia Vera

53
Q

Provides initial hemostasis due to injury

A

Platelet plug

54
Q

Platelet survival

A

8-11 days(in vivo) 3-5 days(in vitro)

55
Q

Water soluble complex of ferric salt and protein

A

Ferritin

56
Q

Production of azurophilic granules

A

Promyelocyte

57
Q

Last stage of granulocytic that capable of mitosis

A

Myelocyte

58
Q

HgB constituent that may degraded and return to amino acid pool

A

Globin

59
Q

Cytokines produced by macrophages and kupffer cell

A

IL-18

60
Q

Not considered myeloproliferative disorder

A

AML

61
Q

Average concentration HgB in a given RBC

A
62
Q

Factor 8 deficiency

A

Hemophilia A

63
Q

Abnormal RBC due to abnormal radium potassium ratio in the RBC

A

Stomatocytes

64
Q

Majority of iron bound to _____ which has capacity to bind 331 mg of iron/dl

A

Transferrin

65
Q

Hematopoiesis begins at the 6th week of fetal life

A

Liver

66
Q

Life span of basophil in bone marrow

A

Seven days

67
Q

Sensitive test in folate or cobalamine deficiency. Measures ability of marrow cells in vitro to utilize deoxyuridine in DNA synthesis

A

Deoxyuridine suppression test

68
Q

Chronic progressive panmyelosis characterized by triad findings vary in fibrosis in the marrow, splenomegaly and leukoerythroblastic anemia

A

Myelofibrosis w/ myeloid metaplasia

69
Q

Useful in identifying w/ Beta-Thalassemia trait that elevated upto 7%

A

HbA2

70
Q

This altered of immune response against host own immune system that produce Antibody against itself:

A

Autoimmune hemolytic anemia

71
Q

Use to connote the appearance of neoplastic cell w/ non-hodgkins lymphoma

A

Lymphosarcoma cell leukemia

72
Q

Rare autosomal dominant shows pale blue inclusion resembling Dohle bodies

A

May hegglin anomaly

73
Q

Not required for RBC production

A

Folic acid
Iron
Protein
Vitamin E

74
Q

Normal Retic Count at birth

A

3-7%

75
Q

Which of the ff refers to total red cell mass

A

Absolute polycythemia vera

76
Q

This are the Pro-Tcell markers except?

A

CD3,
CD 7,
CD2,
CD17

77
Q

Term used if RBC is hypochromic and normochromic:

A

Anosochromia

78
Q

Normal value of reticulated platelet count

A

3-20%

79
Q

Variety of Acute leukemia predominant blasts cannot classify using morphologic, cytochemical, ultrastructural and immunologic or DNA analysis

A

Acute undifferentiated leukemia

80
Q

Hgb not denatured by alkaline solution

A

HbF

81
Q

Fastest Hgb at pH 8.4 in alkaline medium

A

HbH

82
Q

Which of the ff also called CSF-1

A

Monocyte macrophage CSF

83
Q

Genetically impairment of globin synthesis

A

Thallasemia

84
Q

Reveals pancytopenia, decrease hematopoietic cell lines resulting to low all blood levels

A

Aplastic anemia

85
Q

1 g of Hgb carries ___ mg of Iron

A

3.47

86
Q

Abundant blue cytoplasm, eccentric round nucleus w/ light vacuoles w/ well defined golgi zone adjacent to nucleus

A

Plasma cell

87
Q

Bilobed structure which recognized by size and bright red granules

A

Eosinophil

88
Q

Young cells w/ residual RNA polychromatophilic RBC in air dried film stained with __?

A

Brilliant cresyl blue
New ,methylene blue

89
Q

Quantitative measure of Carboxy Hgb

A

Either (Differential spectrophotometer, gas chromatography)

90
Q

Absorbance of spectrophotometer for determining Hgb using HCN

A

540 nm

91
Q

Conjugated protein serves as a vehicle of oxygen and carbon dioxide

A

Hgb

92
Q

Lab findings of DIC:

A

(increase D-dimer, increase PT/PTT, decrease platelet count)

93
Q

Result of PT & PTT mixing studies: mixed plasma is normal, after 1-2 hrs it is prolonged, suggestive of

A

Presence of FVIII inhibitor

94
Q

Cooper Cruick Shank method is for:

A

Absolute neutrophil count

95
Q

Pathway using 2,3-BPG

A

Rapaport-Leubering Shunt

Hematology (2 decks)

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