ID - Target Organisms & Adverse Effects Flashcards
What are the drugs of choice for MSSA?
- Nafcillin (IV)
- Dicloxacillin (PO)
- Cefazolin (IV)
What is the drug of choice for MRSA?
Vancomycin
What is the drug of choice for enterococcus spp?
susceptible to vanc and amp
Ampicillin
What are the drugs of choice for VRE?
vanc resistance enterococcus
- ampicillin (if susceptible)
- linezolid (if pt is SSRI free and platelet count it >50-100)
- daptomycin (if pt is on SSRI)
What are the drugs of choice for pseudomonas aeruginosa?
- piperacillin
- cefepime
- amikacin
What are the drugs of choice for atypicals (legionella)?
- macrolides (azithromycin)
- FQs (moxifloxacin)
doxy if allergy
What is the drug of choice for a monomicrobial infection due to bacteroides spp?
metronidazole
What is the drug of choice for a polymicrobial infection with bacteroides spp and gram negative aerobes?
zosyn (piperacillin/tazobactam)
(ceftriaxone or cipro) with metronidazole in the case of allergy
What is the drug of choice for c. diff colitis?
oral vancomycin
Which drugs cause nephrotoxicity?
- polymyxins
- AMGs
- nafcillin (and other pcns)
- telavancin
- sulfamethoxazole-tmp
- vancomycin
PANTS V
Which drugs interact with warfarin?
- clarithromycin
- erythromycin
- TMP-SMX
- metronidazole
- FQs
Which drugs need to be avoided in pregnancy?
- FQs
- TMP-SMX
- tetracyclines
- telavancin
- metronidazole
fuck the three trimesters, man
Which drugs interact with cations?
- FQs
- tetracyclines
- omadacycline
Which drugs cause QT prolongation?
- FQs
- macrolides
- telavancin
fuck myocardial timings
myocardial -> big heart -> macro
timings -> television -> televancin
Which drugs interact with alcohol to cause disulfiram reaction?
- cefamandole - 2nd gen
- cefotetan - 2nd gen
- cefmetazole - 2nd gen
- cefoperazone - 3rd gen
- moxalactam
- metronidazole
Which drugs penetrate the CSF?
- parenteral pcns
- parenteral cefuroxime
- parenteral ceftriaxone, ceftazidime, cefpodoxime
- parenteral cefepime
- meropenem
- aztreonam
- variable vanc
- TMP-SMX
- metronidazole
Which drugs cover pseudomonas aeruginosa?
- ticarcillin, piperacillin
- ceftazidime, cefoperazone
- cefepime
- imipenem, meropenem, doripenem
- aztreonam
- cipro, levo, dela
- amikacin, tobramycin, gentamycin
- polymyxin B, colistin
Which drugs cover PRSP?
pcn-resistant streptococcus pneumoniae
- cefotetan, cefoxitin (3rd gens)
- cefepime
- ceftaroline
- levo, moxi, dela (newer FQs)
- vancomycin
- Gram-positive crew
Gram-positive crew =
- syndercid
- linezolid, tedizolid
- daptomycin
- telavancin
- dalbavancin
- oritavancin
What are the primary agents for MSSA?
- Nafcillin
- cephalexin, cefazolin
Which drugs cover MRSA?
- ceftaroline
- delafloxacin
- AMGs with help
- vancomycin
- gram-positive crew
- tetracyclines + analogs
- TMP-SMX
Which drugs cover BDA?
- B-lactam inhibitor combos
- piperacillin
- cefoxitin
- cefotetan
- clindamycin
- metronidazole
Which drugs cover c. diff?
- vancomycin
- metronidazole
