Antivirals - Clinical Use Flashcards
1
Q
What are DOCs for HSV 1/2?
A
- acyclovir
- valacyclovir
2
Q
What are DOCs for VZV?
A
- acyclovir
- valacyclovir
3
Q
What are DOCs for CMV?
A
- ganciclovir
- valganciclovir
4
Q
How should acyclovir be dose adjusted?
A
Dose adjust in obesity
5
Q
What are the adverse effects of acyclovir?
A
- nephrotoxicity (reversible)
- neurotoxicity
6
Q
What is the dosing regimen for HSV encephalitis?
A
Acyclovir 10 mg/kg Q8H for 14-21 days (adjusted body weight)
7
Q
How is acyclovir dosed for chickenpox or shingles?
A
800 mg PO Q4H for 5-7 days
8
Q
What are the adverse effects of ganciclovir?
A
- bone marrow suppression
- generally reversible
- incidence increases as cumulative dose increases
9
Q
What is the major dose-limiting adverse effect of foscarnet?
A
nephrotoxicity
10
Q
How soon must oseltamivir, zanamivir, or peramivir be started for the flu?
A
Within 2 days of becoming symptomatic
11
Q
What is the adverse effect of concern for zanamivir?
inhaled drug
A
bronchospasm
