ID/Immuno Flashcards
Treatment for infant born to woman with active TB
isoniazid until 3-4 mo of age until PPD can be placed; continued management dependent on results
2 month vaccines
2B DR HIP
2 months:
hep B
DTaP (diphtheria, tenanus, acellular pertussis)
Rota (not in NICU)
Hib
IPV (inactivated polio)
Pneumococcal
*diptheria and tetanus are toxoid vaccines
Duration of treatment for infant born to maternal untreated gonorrheal infection
tx: both ophthalmic erythro and IV/IM CTX
if disseminated (bacteremia, arthritis) - CTX or cefotax for 7 days
meningitis - 10-14d
most common bacteria a/w osteo in neonates
Staph aureus
less common: GBS, E coli, candida, neisseria gonorrheoae
Most common bones for osteo
femur > humerus > tibia > radius > maxilla
(femur and tibia in preterm; humerus in term)?
CMV virus type
double stranded herpes DNA virus
precautions for CMV+ infant
standard
time of CMV maternal infection w/ greater risk of neonatal disease/greater severity of neonatal illness
FIRST half of pregnancy
radiographic evidence of osteomyelitis - what and when
7-10 days
bony destruction, focal area of metaphysical necrosis, soft tissue swelling
*CT/MR more sensitive but not always possible due to need for transport/sedation
treatment duration for toxo
~1 year
pyrimethamine-sulfadiazine and folinic acid*
(supplement with folate b/c sulfadiazine a/w bone marrow suppression –>neutropenia)
symptoms in neonate of toxo
usually asymptomatic at birth
80% may develop learning disabilities and visual problems later
*preterm may develop CNS symptoms and eye problems in first 3 months of life (compared to later in term) but both at equal risk in general
MCC of EOS (< 72hr)
- overall
- in term
- in VLBW
overall: GBS and E coli
term: GBS
VLBW: E coli (risk of EOS 10x in VLBW than term)
MC serotype of GBS in Late Onset Sepsis
Serotype III
Chediak-HIgashi
abnormal neutrophil degranulation
leads to partial oculocutaneous albinism
nystagmus
peripheral neuropathy
recurrent infections
Leukocyte adhesion deficiency
d/o of neutrophil function despite increased #
defective adhesion and migration
recurrent bacterial infections
poor wound healing
necrotic lesions
*risk of ompholitis
*delayed umbilical cord (sometimes >21d)
Chronic granulomatous disease
abnormal phagocytic microbial ability
increased risk of abscesses
poor wound healing
granuloma formation
Hyper IgE aka Job’s syndrome
abnormal neutrophil chemotaxis
skin infections
coarse facial features
broad nasal bridge
Kostmann
severe congenital neutropenia
frequent infx in first few months
*elastase gene
responds well to rG-CSF
Iso precautions for:
CMV
Rubella
HSV
Toxo
HIV
TB
Varicella
RSV
Parvo
Listeria
Standard:
- CMV
- Toxo
- HIV
- Listeria
Contact only:
- HSV
- RSV
Droplet:
- Rubella (+ contact)
- Parvo
Airborn (+ contact)
- TB
- Varicella*
Congenital varicella does not require contact isolation if no active lesions
Rubella virus type
RNA
passed through respiratory secretions
HSV virus type
double-stranded DNA
Toxo infx type
intracellular parasite
passed by poorly cooked meat, cat feces
HIV virus type
RNA retrovirus
Varicella virus type
DNA herpes
RSV virus type
RNA paramyxovirus
ParvoB19 virus type
single-stranded DNA
Listeria bacteria type
gram-positive rod
Treatment for listeria
ampicillin+aminoglycocide
14 d sepsis
21d meningitis
*consider brain imaging to assess for abscess
maternal infections that increase risk of stillbirth or fetal loss
Listeria
Parvo B19
Syphilis - 30-40% of congenital syphilis=stillborn
when do symptoms of congenital syphillis typically develop
3-14 weeks PNA
(most asymptomatic at birth)
*30-40% chance of stillbirth
CMV hearing loss characteristics
MCC (non genetic) of congenital sensorineural healing loss in children
- progressive (may not be detected until after 1 year of life)
- usually bilateral and moderate to profound
- tx w/ gancyclovir* to infants a/w preservation of hearing
*monitor for nephrotoxicity, neutropenia, rising LFTs
Cardiac disease in congenital Rubella
(50% chance of heart defect)
PDA
Pulmonary arterial hypoplasia
Salt and pepper chorioretinitis
sensorineural hearing loss
cataracts
insulin-dependent diabetes
thyroid disease
Rubella
treatment for congenital rubella
supportive only