ICM 2 Psych Drugs Flashcards
What is diphenhydramine used for?
To treat Dystonia (sustained muscle contraction) due to EPS
What SSRI should you NOT give to children because of the high suicide risk?
Paroxetine
Six SSRIs?
“Effective for sadness, panic, and compulsions”
Escitalopram, Fluoxetine & Fluvoxamine, Sertaline, Paroxetine, and Citalopram
Why are MAOIs rarely prescribed?
They can cause hypertensive crisis (tyramine is normally broken down by MAO & without it tyramine builds up - tyramine responsible for fight or flight response)
What dementia medication is glutamate-based?
Memantine
What medication is most effective in treating acute mania?
Valproate
Three SNRIs?
Venlafaxine
Desvenlafaxine
Duloxetine
What is Dantrolene used for?
To treat Neuroleptic Malignant Syndrome (lead pipe rigidity!!)
What are symptoms of severe Serotonin Syndrome?
diaphoresis, tachycardia, hyperthermia, hypertension, vomiting, diarrhea, muscle rigidity, fever, sweating, restlessness, agitation, delirium, tremor, hyperreflexia, clonus, bilateral Babinski sign
What antidepressant does not cause sexual dysfunction?
Buproprion
Six mood stabilizers?
CLLOT-V
Carbamazepine
Lamotrigine
Lithium
Oxcarbazepine
Topiramate
Valproate
What is the only FDA-approved drug for treating bulimia in adults?
Fluoxetine
What atypical antipsychotic has side effects of sedation and orthostatic hypertension?
Quetiapine
What are the three acetylcholinesterase inhibitor drugs used to treat dementia?
Donepezil, galantamine, rivastigmine
What atypical antipsychotic has a side effect of agrunulocytosis?
Clozapine
What is Eszopiclone used for?
Sleep aid
EsZZZopiclone
What antidepressant class causes QTc prolongation?
TCAs
What class of antidepressants are commonly prescribed for chronic pain and fibromyalgia?
SNRIs
Lithium side effects?
Leukocytosis, heart block, nephrotoxicity, hypothyroid, nephrogenic diabetes insipidus, weight gain, hand tremor
What is Zolpidem used for?
Sleep (its Ambien!)
Which TCA is used to treat GERD?
Doxapine
What is Trazadone commonly used off-label for?
Sleep (side effect of priapism!)
TraZZZa-bone
What TCA is used to treat neuropathy?
Amitriptyline
Which two benzos are easiest on the liver and used to detox cirrhosis/hepatitis patients?
Lorazepam and Temazepam
What is Temazepam used off-label for?
Sleep
What will a patient with discontinuation syndrome present with?
headaches, dysphoric or irritable mood, flushing, dizziness, insomnia, tremor
What antidepressant class is lethal in overdose?
TCAs
What mood stabilizer has questionable efficacy in children?
Oxcarbazepine
Three typical/first gen antipsychotics?
Chlorpromazine, fluphenazine, haloperidol
What is Benzotropine used for?
To treat dystonia (sustained muscle contraction) due to EPS
Two FDA-approved drugs for treating depression in children?
Escitalopram and Fluoxetine
Which two benzos have an increased addiction risk?
Diazepam (valium) and Alprazolam (xanax)
Which benzo is used for treating sleep walking, REM behavior disorder and narcolepsy?
Clonazepam
Five TCAs?
D CAIN (think Danity Cain)
Doxapine, Clomipramine, Amitriptyline, Imipramine, Notriptyline
Which SSRI has a high risk for discontinuation syndrome?
Paroxetine
Three MAOIs?
SIP
Selegiline (B)
Isocarboxazid (A&B)
Phenelzine (A&B)
What mood stabilizer has a high risk for Steven Johnson rash in Asian population?
Carbamazepine
What is Buproprion commonly used for?
Depression (but not anxiety) and smoking cessation
Off-label for ADHD
Mono amine oxidase B breaks down what neurotransmitters?
dopamine
Mono amine oxidase A breaks down what neurotransmitters?
Serotonin and norepinephrine
Side effects of Valproate?
Suicidal ideation, hepatitis/hepatotoxicity, neural tube defects, pregnancy class X, sedation, weight gain, bone marrow suppression, hirsutism, PCOS
What atypical antipsychotic has a side effect of QT prolongation?
Ziprasidone
What class of antipsychotics are stronger D2 blockers?
typical/first gen
What mood stabilizer has a high risk for Steven Johnson rash?
Lamotrigine
What else do atypical antipsychotics block?
5HT2A (serotonin) + 5HT2C & H1 histamine
What TCA is used to treat enuresis?
Imipramine
What is Buspirone used for?
FDA-approved for treatment of Generalized Anxiety Disorder (no panic disorder cross-over); onset of action is 3-4 weeks
Five atypical/second gen antipyschotics?
Aripiprazole, Clozapine, Olanzapine, Quetiapine, Ziprasidone
Who is Mirtazapine commonly prescribed to?
Depressed elderly who experience appetite reduction and insomnia
MirtaZZZapine
What TCA is used to treat OCD?
Clomipramine
