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ACVP Phase II - Clinical Pathology > ICC/IHC/Flow Markers > Flashcards

ICC/IHC/Flow Markers Flashcards

1
Q

Actin sarcomeric

A

striated muscle

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2
Q

Actin smooth muscle

A

smooth muscle

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3
Q

amylin (IAPP)

A

pancreas (islet amyloid)

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4
Q

CD1a

A

cortical thymocytes, langerhans cells, T cell lymphoblastic, dendritic cells, feline progressive systemic histiocytosis, reactive/systemic histiocytosis

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5
Q

CD1c

A

dendritic cells, feline progressive histiocytosis

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6
Q

CD3

A

T cell

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7
Q

CD4

A

T cell (helper), neut, mac

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8
Q

CD5

A

T cell

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9
Q

CD8a

A

T cell

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10
Q

CD8b

A

T cell

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11
Q

CD10

A

Renal, stromal tumors

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12
Q

CD11b

A

granulocytes, monocytes/macs

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13
Q

CD11c

A

granulocytes, monocytes, dendritic cells

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14
Q

CD11d

A

lymphoid, histiocytic tumors

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15
Q

CD14

A

monocytes/macs

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16
Q

CD18

A

leukocytic tumors (mono/mac, granulocyte)

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17
Q

CD20

A

B cell

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18
Q

CD21

A

B cell

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19
Q

CD31

A

vascular endothelial, megakaryocytic tumors, monos

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20
Q

CD34

A

HSC, vascular neoplasms

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21
Q

CD41/61

A

megakaryocytes, PLTs

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22
Q

CD45

A

leukocytic tumors

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23
Q

CD45RA

A

lymphoid tumors

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24
Q

CD68

A

macs, myeloid leukemia

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25
Q

CD71

A

reticulocytes

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26
Q

CD79a

A

B cell

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27
Q

CD90

A

interstitial dendritic cells, reactive/systemic histiocytosis

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28
Q

CD117

A

MCT, GIST, melanoma

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29
Q

CD163

A

histiocytic (phagocytic) sarcoma

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30
Q

CD204

A

histiocytic (phagocytic) sarcoma

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31
Q

Calcitonin

A

C cell (medullary) thyroid tumor

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32
Q

Calponin

A

smooth muscle, myofibroblastic + myoepi tumors

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33
Q

Calprotectin

A

macs, myeloid cells

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34
Q

calretinin

A

renal tubules, nerve tissue, adrenocortical tumors, mesothelioma

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35
Q

chromogranin A

A

neuroendocrine

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36
Q

caludin 1

A

epithelial tumors, meningioma

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37
Q

CNPase

A

PNST (Schwann cells), oligodendroglioma

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38
Q

COX–1

A

normal urothelium, endothelium

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39
Q

cytokeratin 5

A

myoepithelium, epi basal cells, mesothelium

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40
Q

cytokeratin 7

A

glandular epi neoplasms

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41
Q

cytokeratin 8/18

A

glandular epi neoplasms

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42
Q

cytokeratins AE1–AE3

A

general epi cell marker

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43
Q

cytokeratins PAN

A

general epi cell marker

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44
Q

cytokeratins HMW

A

squamous epithelium, mesothelium

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45
Q

desmin

A

muscle tumors

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46
Q

E–cadherin

A

landerhans cells, epi neoplasms, canine histiocytoma, meningioma

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47
Q

F.VIII–related Ag

A

vascular endothelial, megakaryocytic tumors

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48
Q

GATA–4

A

sex cord stromal tumors

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49
Q

GFAP

A

neural (glial) tumors, astrocytoma

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50
Q

glut 1

A

peripheral nerves, stromal cells, kidney

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51
Q

glycophorin A

A

erythroid leukemia

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52
Q

inhibin–alpha

A

sex cord stromal, adrenocortical tumors

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53
Q

Ki–67

A

cell proliferation markers

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54
Q

laminin

A

PVWT, basement membrane

55
Q

lysozyme

A

histiocytes (macs)

56
Q

LYVE–1

A

lymphatic endothelial tumors

57
Q

melan–A

A

melanocytic neoplasms, steroid–producing tumors

58
Q

MHCII

A

mac, dendritic lineage, APCs, lymphs

59
Q

microphthalmia transcription factor

A

melanocytic neoplasms

60
Q

MPO

A

granulocytic leukemia

61
Q

MyoD1

A

rhabdomyosarcoma

62
Q

myoglobin

A

skeletal muscle tumors

63
Q

myosin

A

smooth muscle tumors

64
Q

NSE

A

neuroendocrine

65
Q

OCT–3/4

A

germ cells, stem cells

66
Q

Olig–2

A

oligodendroglioma

67
Q

p63

A

myoepithelium, epi basal cells, urothelial tumors

68
Q

pax5

A

B cell

69
Q

PCNA

A

proliferation marker

70
Q

protein gene product 9.5

A

neuroendocrine

71
Q

prox–1

A

lymphatic endothelial tumors

72
Q

S100

A

neural marker, neuroendocrine tumors

73
Q

somatostatin

A

pancreatic islet tumor, some carcinoids

74
Q

synaptophysin

A

neuroendocrine

75
Q

tryptase

A

MCT

76
Q

tyrosinase

A

melanocytic tumors

77
Q

uroplakin III

A

urothelial tumors

78
Q

vimentin

A

mesenchymal tumors

79
Q

Adrenal cortex

A

melan–A, inhibin–alpha, calretinin

80
Q

adrenal medulla

A

PGP 9.5, chromogranin, synaptophysin

81
Q

endocrine (generic)

A

chromogranin A, synaptophysin, PGP 9.5, NSE, S100

82
Q

epithelial (vs mesenchymal)

A

cytokeratins, E–cadherin, claudin–1, p63

83
Q

mesenchymal (vs epithelial)

A

vimentin, p63

84
Q

hepatocytes

A

hep par 1

85
Q

biliary epithelium

A

cytokeratin 7, 19

86
Q

all muscle

A

actin muscle, desmin

87
Q

skeletal muscle

A

actin sarcomeric, myoglobin

88
Q

smooth muscle

A

calponin, SMA

89
Q

SCC

A

CK5, p63

90
Q

adenocarcinoma

A

CK7, CK8/18

91
Q

sex–cord stromal tumor

A

inhibin–alpha, NSE

92
Q

germ cell tumor

A

calretinin, KIT, Oct3/4, PGP 9.5

93
Q

thyroid follicular cell

A

thyroglobulin

94
Q

thyroid medulla, C cell

A

calcitonin

95
Q

endothelial tumors

A

F.VIIIrp, CD31, CD34 (blood and lymphatic); LYVE–1, Prox–1 (lymphatic)

96
Q

histiocytic sarcoma

A

CD18+, CD11d–

97
Q

hemophagocytic sarcoma

A

CD18+, CD11d+

98
Q

cutaneous histiocytoma

A

e–cadherin+, CD45+, vimentin+

99
Q

alcian blue

A

sialomucins, hyaluronic acid, sulfated mucosubstances

100
Q

alizarin red S

A

calcium

101
Q

best carmine

A

glycogen

102
Q

bielschowsky silver stain

A

axons

103
Q

congo red

A

amyloid

104
Q

cresyl violet

A

nissl substance

105
Q

dunn–thompson

A

Hb

106
Q

feulgen

A

DNA

107
Q

fontana–masson

A

melanin

108
Q

gordon and sweets reticulin fiber

A

reticulin fibers

109
Q

grimelius

A

argyrophilic granules

110
Q

hall

A

bile/biliverdin

111
Q

jone methenamine

A

basement membrane

112
Q

kinyoun (mod Ziehl–neelsen)

A

lipofuscin

113
Q

luxol fast blue

A

myelin

114
Q

mallory PTAH

A

muscle, fibrin, glial processes

115
Q

masson trichrome

A

muscle, collagen

116
Q

mayer mucicarmine

A

mucin, hyaluronic acid, chondroitin sulfate

117
Q

methyl green pyronin

A

nucleic acids

118
Q

oil red o

A

fat

119
Q

PAS

A

glycogen, mucin

120
Q

prussian blue

A

iron

121
Q

rhodanine / rubeanic acid

A

copper

122
Q

schmorl reaction

A

melanin, lipofuscin

123
Q

toluidine blue

A

mast cells

124
Q

verhoeff

A

elastic fibers

125
Q

von kossa

A

calcium

126
Q

jimenez, macchiavello

A

chlamydiae

127
Q

wade–fite, ziehl–neelsen

A

acid fast bacteria

128
Q

CD16 / CD56

A

NK cell

129
Q

LMW cytokeratins

A

CK 7,8,18

130
Q

HMW cytokeratins

A

CK 1–6,9,10,14

131
Q

osteoblasts

A

ACP, ALP, osteocalcin

132
Q

osteoclasts

A

TRAP, RANK, MHCII

133
Q

hibernoma

A

UCP–1

134
Q

sudan black B, osmium

A

lipid

ACVP Phase II - Clinical Pathology (14 decks)

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