IC9 & 10 Flashcards
What does Tamoxifen act as?
Acts as a selective estrogen receptor modulator (SERM)
Is Cis/ trans isomer of Tamoxifen used for breast cancer?
Trans; to display anti-estrogenic activity
What is tamoxifen used mainly for?
breast cancer
What is pembrolizumab used mainly for?
cervical cancer
Bicalutamide - why cannot use as monotherapy for prostate cancer?
Blocks A -> incr LH secretion -> (+) higher serum testosterone levels
Bicalutamide & Leuprorelin - indication?
Prostate cancer
Prostate growth depends on androgens (T/F)
True
How is pembrolizumab metabolised?
General protein degradation (recall: Mabs are big in size)
Dosage form for pembrolizumab
IV
Does pembrolizumab bind to plasma protein?
No
Does tamoxifen bind to plasma protein?
Yes, Plasma protein binding > 98%
Action of pembrolizumab
PD1-blocker
(basically prevent PD-L1 on tumour cells from binding to PD-1 that would inactivate T cell action
What should be stopped when initiating pembrolizumab? (added back aft initiation)
- Corticosteroids
- Immunosuppressants
Contraindication for pembrolizumab
- Pregnant women
- Hypersensitivity
DDI for tamoxifen
CYP3A4 inhibitor & CYP2D6 inhibitors (incr conc of tamoxifen)
Dosage form for leuprorelin
IV/IM/SC
Action of leuprorelin
GnRH analogue -> inhibits FSH and LH release -> decr androgen synthesis -> decr testosterone production -> apoptosis of prostate cancer cells