IC15 Anxiety & Sleep Disorders Flashcards

1
Q

What is Anxiety Disorders?

A

Anxiety disorder is a condition where anxiety starts to impair function.

The irrational fear and anxiety that a pt faces is severe, excessive, and persistent to the point where it impairs function with daily living.

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2
Q

What are the 5 types of anxiety disorders that we learn in this IC?

A
  1. Generalized Anxiety Disorder (GAD)
  2. Panic Disorder (PD)
  3. Social Anxiety Disorder (SAD)
  4. Obsessive Compulsive Disorder (OCD)
  5. Post-Traumatic Stress Disorder (PTSD)
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3
Q

What is considered common in terms of percentages of a disease?

E.g. OCD has a prevalence of 3.6% in Singapore

A

Anything that is more than 1-2% is considered common.

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4
Q

What is the definition of the 5 types of anxiety disorders?

  1. Generalized Anxiety Disorder (GAD)
  2. Panic Disorder (PD)
  3. Social Anxiety Disorder (SAD)
  4. Obsessive Compulsive Disorder (OCD)
  5. Post-Traumatic Stress Disorder (PTSD)
A

GAD - excessive anxiety & worries ≥ 6 months

PD - anticipatory anxiety of recurrent panic attacks

SAD - fear of being scrutinized or humiliated by others in public

OCD - Obsessional thoughts/impulses that causes anxiety, followed by compulsive behaviours to relieve that anxiety

PTSD - Re-experiencing of trauma, Persistent Avoidance, Increased arousal

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5
Q

What are the neurotransmitters involved in anxiety?

A
  1. Noradrenaline
  2. Serotonin
  3. GABA
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6
Q

What are possible medical conditions that are associated with anxiety?

(1) Cardiovascular - ?
(2) Endocrine - ?
(3) Neurologic - ?
(4) Pulmonary - ?

A

(1) Cardiovascular - Heart failure
(2) Endocrine - Hyperthyroidism
(3) Neurologic - Dementia, Delirium
(4) Pulmonary - Asthma, COPD

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7
Q

What are some drug classes that can cause drug induced anxiety?

A
  1. Stimulants - a class of drug that can increase norepinephrine & dopamine levels
  2. Corticosteroids
  3. Antidepressants - e.g SSRI, SNRI
  4. Dopamine agonists
  5. Others - levothyroxine, caffeine and etc.

Other possible drug-related causes of anxiety are:
- Drug withdrawal, such as opioid or Benzodiazepine
- Drug intoxication

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8
Q

What is the definition of Generalized Anxiety Disorder (GAD)?

A

GAD is defined as excessive anxiety & worry occurring for ≥6 months about a number of events or activities.

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9
Q

What are the S&S that a pt must present for ≥6 months to be diagnosed w GAD?

A

Pt must present with ≥3 S&S of:

  1. Restlessness
  2. Easily fatigued
  3. Difficulty concentrating
  4. Sleep disturbances
  5. Irritability
  6. Muscle tension
    REDSIM
    for ≥ 6 months.

The symptoms cause significant functional impairment.

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10
Q

What is the criteria to diagnose a pt with panic disorder (PD)?

A

Patient must present with both (1) and (2):

(1) Recurrent unexpected panic attacks
(2) ≥1 panic attacks leading to ≥ 1 month of the following:
- Persistent anticipatory anxiety
- Worry about outcomes of the panic attack
- Significant change in behaviour related to the panic attacks

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11
Q

What is the criteria to diagnose a pt with social anxiety disorder (SAD)?

A

A pt must present w these fear for ≥6 months:

      - Marked & persistent fear of ≥1 social situations, which the person is exposed to scrutiny by others. 
      - The person fears that they will act in a way that is humiliating or embarrassing.

This fear is so bad that it impairs function.

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12
Q

A pt w Obesessive-Compulsive Disorder (OCD) will present with either obsessions or compulsions.

What is considered as obsession and compulsion?

A

Obsession:
- Recurrent & persistent thoughts that are intrusive and inappropriate, causing anxiety.
- Person knows that the obsession is a product of his own mind

Compulsion:
- Repetitive behaviours or mental acts that a person feels driven to do in a response to an obsession.
- Behaviours are aimed to prevent and reduce distress, but are clearly excessive and not connected in a realistic way.

These obsessions and compulsions can be time consuming or significantly impairs function.

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13
Q

What is the difference between OCD and psychosis?

A

OCD patients are aware that their thoughts are irrational, whereas psychosis patients are unaware and they totally believe their thoughts.

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14
Q

What is the process of a pt developing PTSD?

A
  1. Person is exposed to a threat, death, serious injury, sexual violence and etc.
  2. Traumatic event is persistently re-experienced
  3. Pt puts in persistent effort to avoid any trauma stimuli
  4. Pt’s mood and cognition begins to worsen
  5. Trauma-related alterations can lead to arousal and reactivity - such as aggressive behaviour, sleep disturbances
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15
Q

What assessment tool can you use to assess the severity of a pt’s anxiety?

A

The Hamilton Anxiety Scale (HAM-A)

HAM-A is the GOLD standard to use, to assess a pt’s anxiety severity.

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16
Q

What are the possible treatments for GAD?

A

Non-pharmacological:
- Cognitive Behavioural Therapy (CBT)
- CBT to be used w medications

Pharmacotherapy:
- SSRIs
- Venlafaxine XR
- Pregabalin

17
Q

What are the possible treatments for PD?

A

Non-pharmacological:
- Cognitive Behavioural Therapy (CBT)
- CBT to be used w medications

Pharmacotherapy:
- SSRIs

18
Q

What are the possible treatments for Social Anxiety Disorder (SAD)?

A

SSRIs

19
Q

What are the possible treatments for OCD?

A

Non-pharmacological:
- Cognitive Behavioural Therapy (CBT)
- CBT to be used w medication

Pharmacotherapy:
- SSRIs
- Clomipramine

20
Q

What are the possible treatments for PTSD?

A

Non-pharmacological:
- Cognitive Behavioural Therapy (CBT)
- CBT to be used w medication

Pharmacotherapy:
- SSRIs

21
Q

Recall from depression IC:
What are examples of serotonergic antidepressants?

A
  1. SSRIs (escitalopram, fluoxetine)
  2. SNRIs (venlafexine XR, duloxetine)
  3. Clomipramine (a TCA)
22
Q

What is the approach to dosing when it comes to antidepressants?

A

Start low, go slow.

Starting dose must be low.

Maintenance dose may be high at the end of the range.

23
Q

How does antidepressants help in anxiety patients?

A

Antidepressants are effective for excessive worrying type of symptoms.

Antidepressants take about 4-8 weeks for their onset.

Full response takes about 3 months.

24
Q

How does benzodiazepines help in anxiety patients?

A

Benzodiazepines are effective for physical symptoms.

Benzodiazepines should be used for short term.

E.g of benzodiazepines: Clonazepam, lorazepam, alprazolam XR (most potent & for panic disorder)

25
Q

Lorazepam is the most commonly used benzodiazepine.

Why is lorazepam a good benzodiazepine to use?

A
  1. It’s duration of action is short.
  2. It doesn’t accumulate in the liver
  3. Has low toxicity
26
Q

Here are some common DDIs that we have learnt so far:
1. Alcohol & other CNS depressants
2. MAOIs & SSTIs/TCAs
3. Benzodiazepines + Opioids
4. Anticholinergic agents

What are the ADRs that can come about when these agents are used tgt?

A
  1. Alcohol & other CNS depressants - can lead to ↑ CNS depression side effects
  2. MAOIs & SSTIs/TCAs - can cause serotonin syndrome
  3. Benzodiazepines + Opioids - ↑ mortality, respiratory depression
  4. Anticholinergic agents can cause excessive anticholinergic effects
27
Q

What is insomnia?

A

Insomnia is a type of sleep disorder that can make it hard to fall asleep or stay asleep.

28
Q

There are 2 types of insomnia:
1. Acute (<4 weeks)
2. Chronic (>4 weeks)

How to manage the 2 types of insomnia?

A
  1. Acute:
    - Sleep hygiene
    - Short PRN course of hypnotic.
  2. Chronic:
    - Likely secondary to underlying psychiatric and/or medical problems.
    - Investigate and manage underlying condition
    - Discourage long-term use of hypnotic
29
Q

What are pharmacological therapies for insomnia?

A

We want fast-acting:
- Anxiolytic / sedative / hypnotics

Anxiolytics are drugs that relieve anxiety.

These pharmacotherapy are used for short-term relief.

30
Q

What is the general rule we follow when giving pharmacotherapy for insomnia?

A

We want to give:
- Lowest effective dose
- PRN dosing
- Short course (1-2 weeks)

31
Q

What is sleep hygiene?

A
  1. Avoid the use of caffeine-containing products, nicotine & alcohol
  2. Avoid heavy meals 2hrs before bedtime
  3. Avoid drinking fluids after dinner
  4. Avoid environments that will make you really active after 5pm
  5. Establish a routine
  6. Avoid daytime naps
  7. Have regular physical activities
32
Q

What are 4 examples of hypnotics?

A
  1. Benzodiazepines - best is lorazepam
  2. Z-hypnotics
  3. Antihistamines
  4. Lemborexant
33
Q

What are things to be careful of in the 4 hypnotics?

  1. Benzodiazepines - best is lorazepam
  2. Z-hypnotics
  3. Antihistamines
  4. Lemborexant
A
  1. Benzodiazepine and Z-hypnotics should NOT be given to patients w:
    - Respiratory depression
    - Glaucoma
    - Myasthenia gravis
    - Hypersensitivity

Myasthenia Gravis - a chronic autoimmune disorder in which antibodies destroy the communication between nerves and muscle, resulting in weakness of the skeletal muscles.

  1. Antihistamines
    - Significant anti-cholinergic effects
  2. Lemborexant
    - To avoid in narcolepsy

Narcolepsy - a sleep disorder that makes people very drowsy during the day

34
Q

What is neuroleptic malignant syndrome?

What is akathisia?

A

Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency associated with the use of antipsychotic agents and characterized by a distinctive clinical syndrome of mental status change, rigidity, fever, and dysautonomia.

Akathisia is defined as an inability to remain still.