IBS Flashcards

1
Q

When would you consider assessment for IBS?

A

Patient reports having any of the following symptoms for at least 6 months (ABC):
• Abdominal pain or discomfort
• Bloating
• Change in bowel habit

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2
Q

What symptoms and signs support the diagnosis of IBS?

A

Colicky abdominal pain or discomfort that is:
• Relieved by defecation
• Associated with altered bowel frequency

And 2 of the following:
• Altered stool passage (straining, urgency, incomplete evacuation)
• Abdominal bloating, distention, tension or hardness
• Symptoms made worse by eating
• Passage of mucus

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3
Q

What other non-GI symptoms may support a diagnosis of IBS?

A
  • Lethargy
  • Nausea
  • Backache
  • Bladder symptoms
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4
Q

What tests would you do for IBS?

A
  • FBC
  • Coeliac serology (EMA or TTG)
  • Faecal calprotectin
  • CRP
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5
Q

What are the subtypes of IBS?

A
  • Diarrhoea predominant (IBS-D)
  • Constipation predominant (IBS-C)
  • Mixed
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6
Q

What are the red flags for further investigations?

A
  • > 60yrs
  • Rectal bleeding
  • Anaemia
  • Weight loss
  • Fam Hx colorectal cancer
  • Abdominal/rectal mass
  • Raised CRP/ESR or faecal calprotectin
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7
Q

What would you do if a woman >50 presents with persistent bloating?

A

Need to rule out ovarian cancer
• USS of ovaries
• Ca125 levels

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8
Q

What requires an urgent referral for screening for colorectal cancer?

A
  • > 40 with unexplained abdominal pain and weight loss
  • > 50 with unexplained rectal bleeding
  • > 60 with changes in bowel habit or unexplained iron deficiency anaemia
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9
Q

How do you behaviourally manage IBS?

A
  • Identify associated stress, anxiety, depression and manage appropriately
  • Keep a food diary and look for any obvious food triggers
  • Encourage physical activity
  • Probiotics for at least 4 weeks
  • Low FODMAP diet
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10
Q

How do you behaviourally manage IBS-D?

A

o Reduce fibre intake

o Reduce caffeine, alcohol, carbonated drinks and gas-producing foods

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11
Q

How do you behaviourally manage IBS-C?

A

o Fibre supplements (ispaghula) or foods high in solute fibres (oats)

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12
Q

For constipation, what pharmacological treatment would you give?

A

Laxatives

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13
Q

What are bulk-forming laxatives?

A

Retain fluid within the stool and increase faecal mass, stimulating peristalsis and have stool-softening properties

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14
Q

Give examples of bulk-forming laxative

A
  • Ispaghula husk (Fybogel)

- Methylcellulose

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15
Q

What are osmotic laxatives?

A

Increasing amount of fluid in the large bowel producing distention, which stimulates peristalsis

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16
Q

Give examples of osmotic laxatives

A
  • Lactulose (not recommended in IBS)
  • Macrogols
  • Phosphate and sodium citrate enemas
17
Q

What are stimulant laxatives?

A

Cause peristalsis by stimulating colonic nerves (senna) or colonic and rectal nerves (bisacodyl, sodium picosulfate)

18
Q

What are Prokinetic laxatives?

A

Prucalopride -> 5HT4 receptor agonist, which stimulates intestinal motility

19
Q

What would you give to a patient who has had constipation for >12 months and has received optimal doses of laxatives from different classes?

A

Linaclotide

- 290 microgram capsules 30 mins before meals

20
Q

For diarrhoea, what pharmacological treatment would you give?

A

o Loperamide 4mg, followed by 2mg for up to 5 days, dose to be taken after each loose stool; usual dose 6-8mg daily, max 16mg o.d

21
Q

For abdominal pain, what pharmacological treatment would you give?

A
  • 1st Antispasmodic drugs
  • 2nd Low-dose tricyclic antidepressant
  • 3rd SSRI
22
Q

Give examples of a smooth muscle antispasmodic drug

A
  • Mebeverine (colofac)
  • Alverine (spasmonal)
  • Peppermint (colpermin)

Preferred to anticholinergics as cause less SE

23
Q

Give examples of an anticholinergic antispasmodic drug

A
  • Dicycloverine (merbentyl)
  • Hyoscine (buscopan)
  • Propantheline (probanthine)
24
Q

Give examples of TCA drug

A

Amitriptyline

25
Q

Give examples of SSRI drug

A
  • Citalopram

- Fluoxetine