IBDs Flashcards
1
Q
what happens in coeliac disease?
A
inflammation of upper region of small intestine
2
Q
what is the major protein in gluten?
A
alpha-gliadin
3
Q
what happens to the protein for immune recognitionin coeliac disease?
A
must undergo deamination by tTG
converts glutamine to glutamic acid
4
Q
what does aberrant priming of IFN-gamma produce?
A
CD4+ T cells by antigenic peptides
5
Q
where are the major genes for coeliac disease?
A
on the Human leukocyte antigen region (HLA)
–highly polymorphic
6
Q
what is gout?
A
form of inflammatory arthritis
7
Q
what is gout due to?
A
hyperuricemia (excess uric acid)
- crystals deposit in joints
8
Q
what happens if the uric acid isn’t phagocytosed effectively?
A
crystals pierce cells causing release of lysosomal enzymes
9
Q
A
