IBD ( Inflammatory Bowel Disease ) Flashcards
The term inflammatory bowel disease (IBD) is used to represent 2 distinctive disorders of idiopathic chronic intestinal inflammation………?
Crohn disease
Ulcerative colitis
The most common time of onset of IBD……?
Preadolescent/adolescent era and young adulthood.
A bimodal distribution has been shown with an early onset at 10-20 yr of age and a second, smaller peak at 50-80 yr of age
The risk of occurrence of IBD among relatives of patients with………?
Crohn disease is somewhat greater than for patients with ulcerative colitis.
The concordance rate in twins is…….
Higher in Crohn disease (36%) than in ulcerative colitis (16%).
Genetic disorders that have been associated with IBD include……
Turner syndrome,
the Hermansky-Pudlak syndrome,
glycogen storage disease type Ib, and
various immunodeficiency disorders
A perinuclear antineutrophil cytoplasmic antibody is found in approximately……….?
70% of patients with ulcerative colitis compared with <20% of those with Crohn disease
Approximately 55% of those with Crohn disease are positive for…….?
Anti–Saccharomyces cerevisiae antibody.
Multiple environmental factors are recognized to be involved in the pathogenesis of IBD………. Most important one …….
G’ut microbiota
Some important predisposing factors in IBD……?
Residence in or immigration to industrialized nations,
A Western diet,
increased use of antibiotics at a younger age,
high rates of vaccination, and
less exposure to microbes at a young age
Vit d deficiency
Passive smoking 🚬
CIgarette smoking relation to IBD…….?
A risk factor for Crohn disease but paradoxically protects against ulcerative colitis.
Child initially believed to have ulcerative colitis on the basis of clinical findings is subsequently found to have Crohn colitis. Reason……?……
This is particularly true for the youngest patients, because Crohn disease in this patient population can more often manifest as exclusively colonic inflammation, mimicking ulcerative colitis.
Extraintestinal manifestations occur slightly more commonly with……?
Crohn disease than with ulcerative colitis
Which manifestations correlates with activity of the bowel disease.?
The presence of some manifestations, such as peripheral arthritis, erythema nodosum, and anemia,
Which extra intestinal manifestations doesn’t correlate with intestinal disease….?
sclerosing cholangitis, ankylosing spondylitis, and sacroiliitis
Activity of pyoderma gangrenosum correlates less well with activity of the bowel disease,
In IBD Arthritis occurs in 3 patterns……?
migratory peripheral arthritis involving primarily large joints,
ankylosing spondylitis, and
sacroiliitis
