IBD Drugs Flashcards
5-ASA agents for UC
“sala”
- Sulfasalazine
- Mesalamine
- Olsalazine
- Balsalazide
JAK inhibitor for UC
Tofacitinib (Xeljanz)
IL-12/23 Inhibitor for UC and CD
Ustekinumab (Stelera)
- Used in psoriatic arthritis as well
TNF-a Inhibitors for UC and CD
Adalimumab
Infliximab
TNF-a Inhibitors for UC ONLY
Golimumab
TNF-a Inhibitors for CD ONLY
Certolizumab
a-4 Integrin Inhibitor for UC and CD
Vedolizumab
“Hold up 2 fingers (CD+UC) and it makes a V
a-4 Integrin Inhibitor for CD ONLY
Natalizumab
How do the 5-ASA’s work?
COX inhibitors that decrease PG and LT production which leads to decreased PMN and Mo chemotaxis.
May also inhibit NFKB
A patient presents with pyoderma gangrenosum and Uveitis. She states she is allergic to sulfa drugs. What first line drug do you NOT prescribe for her most likely diagnosis?
Sulfasalizine (UC)
What reported allergy would make the 5-ASA drugs contraindicated?
Aspirin allergy
A patient presents with hematochezia, LLQ pain, and on endoscopy shows pseudo polyps. Which 5-ASA drug is NOT included in your plan?
Olsalazine- maintenance only
How do the TNF-a inhibitors work?
Bind to and inhibit soluble and transmembrane TNF-a
Which TNF-a inhibitor does not have an Fc portion?
Certolizumab
What test must be done prior to administration of a TNF-a inhibitor?
TB test.
Could be latent, don’t want to reactivate
How do a-4 integrin inhibitors work?
Inhibit binding of leukocytes to epithelial cells thus preventing transmigration
What infection must be monitored as a possible side effect of natalizumab?
Progressive Multifocal Leukoencephalopathy
MOA of IL-12/23 inhibitors
bind p40-subunit of the interleukin to block it’s activation effect on T-cells
JAK Inhibitors MOA
Prevent binding and phosphorylation of STAT cascade which decreases pro-inflammatory gene transcription
What is usually a part of IBD treatment that is not covered in this section but still important?
Corticosteroid administration
