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Module 1 Genetics > IBD > Flashcards

IBD Flashcards

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Biology 101 flashcards
1
Q

CARD15/NOD 2

A

Crohn’s

2 variants = 20-40x risk
Card15 gene codes for nod 2 
Nod 2 on membrane of paneth cells as pattern recognition receptor
Recognises LPS
Activates Nfkb

Loss of function - reduced clearing of LPS, more inflammation

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2
Q

ATG16L1

A

Involved in removal of intracellular microbes

Increased Crohns risk

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3
Q

IL23R

A

Protective for CD and UC

Generation of Th17 cells - remove microbes?

GWAS

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4
Q

HLA DRB1

A

Disease modifying role

Refractory UC, colonic Crohns

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Module 1 Genetics (5 decks)

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