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Module 1 Genetics > ALD > Flashcards

ALD Flashcards

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Biology 101 flashcards
1
Q

Major pathway

A

ALDH2 - acetaldehyde dehydrogense isoform, slower metabolism of acetaldehyde into acetate = build up

ADH1B - gain of function, excess acetaldehyde due to over active alcohol dehydrogenase

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2
Q

Candidate genes

A

PNPLA3
TM6SF2
MBOAT7

All have roles in accumulation of lipids in the liver leading to fatty liver

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3
Q

Epigenetics

A

Oxidative stress
Histone modification
Abnormal gene expression

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Module 1 Genetics (5 decks)

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