IBD Flashcards
Inflammatory Bowel Disease (IBD)
general
Term that describes disorders involving long-standing (chronic) inflammation of the digestive tract caused by an abnormal immune response in the bowel
Occurs in genetically susceptible individuals
Types include:
Crohn’s disease
Ulcerative colitis
Differentiation:
Location and depth of involvement in the bowel wall
Spectrum of disease:
Mild symptoms – debilitating condition with life-threatening complications
Crohn’s Disease
general
Chronic, recurrent condition that causes patchy transmural inflammation that can involve any part of the gastrointestinal tract (mouth to anus)
Epidemiology:
Incidence:bimodal distribution
15–25 years(slightly younger average than in ulcerativecolitis)
Smaller peak occurs between 50 and 70 years of age
Most common among whites and eastern European (Ashkenazi) Jews
“skip lesions”
Crohns
RF
Smoking- (not a RF for UC)
Genetics:
HLA-B27
NOD2gene mutation → affects the body’s ability to recognize and attack luminal pathogens (bacterial)
Family historyofIBD
Twin concordance rate is 55%
15% ofpatientswith CD have an affected first-degree relative
Decreased physical activity
Decreased fiber intake
Increased dietary fat intake
Crohns
patho
Multifactorial
Combination of dysregulation of the intestinalepithelium and theimmune system
Mutations of the NOD2gene→ defects in the epithelial barrier of the gastrointestinal (GI) tract → more pathogens penetrate the GI tract →recruitmentand activation ofcytotoxiccells that release pro-inflammatory cytokines →intestinal inflammation
Lack of thedown-regulationof immune responsiveness →chronic inflammation → granulomas
Intestinal tissue damage includingedema, ulcerations, erosions, andnecrosis
Inflammationis transmural and may lead tointestinal perforation and fistulas
Chronic and repetitive episodes →scarring,fibrosis, and obstruction of the intestinal wall
Crohn’s
Location & Pattern of Inflammation
May include any portion of the GI tract
The most common sites:
Terminal ileum
Proximal colon
Associated withskip lesions (discontinuous patchy inflammation)
Therectum is often spared
Inflammation extends through the entire thickness of the bowel wall
Crohns
General manifestations
Low-grade fever
Fatigue
Loss of appetite
Weight loss
Crohns
GI manifestations
- Chronic, intermittent,diarrhea (usually non-bloody)
-
Crampyabdominal pain(diffuse or localized to theright lower quadrant)
Flatulence andbloating - Signs ofmalabsorption with vitamin B12and D deficiencies andiron deficiencyanemia
gallstones more common in Crohns (not UC)
Crohn s
Extraintestinal manifestations
- Aphthous ulcers
- Gallstones → decreased bile acid reabsorption
- Pyoderma gangrenosum: rapidly progressive painful, red papules → pustules → deep ulcers with centralnecrosis
- Erythema nodosum: painful, red nodules that usually appear on theshins
- Eyeinflammation(uveitis,iritis, episcleritis)
- Peripheralarthritis,ankylosing spondylitis, orosteoporosis
aphthous ulcers, erythema nodusum, pyoderma gangrenosum
chrohns
lab Dx
Complete blood count → anemia,leukocytosis, and thrombocytosis
Basic metabolic panel → electrolyte imbalance
↑ESR and CRP
Malabsorption evaluation
Fecal calprotectin (concentrations demonstrate good correlation with intestinal inflammation)
crohns
Stool studies
May be used to exclude other causes of inflammatory diarrhea
Clostridioides difficiletoxin studies in cases of recent antibiotic use
Crohns
Imaging
Imaging Studies
CT scan of abdomen and pelvis, abdominal MRI, or abdominal x-ray with barium swallow
Assess the extent and severity of disease as well as any complications (perforation, fistulas, abscess, stenosis)
Signs of intestinal inflammation: wall thickening with mucosal enhancement, distortion, and hyperintensity
Narrowing of the intestinal lumen giving a “string sign”
Crohns
Endoscopy/Colonoscopy
with biopsy
Gold standard for diagnosis
Transmural inflammation
Skip lesions in any portion of the GI tract, usually sparing therectum
Ulcers, fissures, and fistulas (cobblestone appearance)
Crohns
Drug classes for Tx (4)
- Abx
- corticosteroids
- immunomodulators
- biologics
crohns
Antibiotics
Metronidazole or ciprofloxacin
Used for complications such as abscesses and fistulas
crohns
Corticosteroids
Budesonide (mild) or prednisone (moderate-severe disease)
Used for acute disease flare-ups
Duration is limited due to complications of long-term use