IBD Flashcards
Is there a genetic component to IBD?
Yes, patients with Crohn’s have increased risk of Crohn’s in fam, increased risk of UC relative to general public and vice versa
What is the risk of developing IBD in a child with 2 parents with IBD?
33%
Three genetic diseases that IBD is associated with?
Turner Syndrome
Hermansky-Pudlak Syndrome (oculocutaneous albanism, pulmonary fibrosis, platelet dysfunction)
Glycogen storage disorders
What is Hermansky Pudlak Syndrome
Oculocutaneous albanism
Platelet dysfunction
pulmonary fibrosis
Associated with IBD
Cecal patch?
UC can have an isolated cecal patch even if only left colon is involved
Two classes of meds at can mimic IBD?
Immune checkpoint inhibitors
Anti-IL17 agents (secukinumab, ixekizumab) used to tx psoriasis
Crohn’s mimickers?
NSAID injury
Behcet’s
Small bowel lymphoma (which can cause a stricture)
Which patients are particularly sensitive to yersinia?
Those with iron overload (Hemochromatosis)
Difference of Crohn’s peripheral arthropathy from other immune mediated arthopathies?
No joint erosion, no permanent deformity, seronegative
Episcleritis vs scleritis vs uveitis?
Episcleritis = redness, no visual changes
Scleritis = redness, pain, pain with movement, slightly decreased vision
Uveitis= emergency, pain, photophobia, decreased vision. Can lead to blindness
Screen for osteoporosis in IBD?
Yes, dexa at 65 for women, 70 for men
Which IBD patients need yearly colonoscopy?
Those with PSC, those with severe pseudopolyposis, those with moderate-severe inflammation, those with FDR with CRC <50. Those with IPAA
Which IBD patients need q2-3 year colonoscopy?
Those with mild inflammation, those with fam hx of CRC <50 not in FDR, previously severe colitis
Which IBD patients need q5 year colonoscopy?
Those in remission
Lab to check before starting tofacitanib?
Lipid panel
