I - Water and pH Flashcards

1
Q

Body Weight: % Dry Body Weight

A

40%

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2
Q

Body Weight: % Water

A

60%

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3
Q

Body Weight: % ICF

A

40% (2/3 of water)

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4
Q

Body Weight: % ECF

A

20% (1/3 of water)

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5
Q

Body Weight: % Interstitial Fluid

A

15% (3/4 of ECF)

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6
Q

Body Weight: % Blood Plasma

A

5-7% (1/4 of ECF)

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7
Q

Which elements can water for hydrogen bonds with?

A

-S, -O, -N

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8
Q

Both an acid and a base

A

Amphoteric

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9
Q

Has both hydrophilic and hydrophobic parts

A

Amphipathic

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10
Q

Donates protons

A

Acid

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11
Q

Accepts protons

A

Base

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12
Q

pH =

A

-log [H+]

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13
Q

pOH =

A

-log [OH-] or 14 - pH

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14
Q

Normal pH of blood

A

7.35-7.45

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15
Q

pH where reaction happens optimally

A

pKa (50% protonated, 50% unprotonated)

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16
Q

Charge of acids at physiologic pH

A

(-) negative

17
Q

Charge of bases at physiologic pH

A

(+) positive

18
Q

Causes of HAGMA

A

Methanol, Uremia, Diabetic Ketoacidosis, Paraldehyde / Propylene Glycol, Isoniazid, Lactic Acidosis (sepsis, shock), Ethylene Glycol, Salicylates

19
Q

pH = pKa + log [A-]/[HA] or [B]/[HB+]

A

Henderson-Hasselbalch Equation

20
Q

For titration of amino acids, predictng shifts in the bicarbonate buffer system and predicting distribution of drugs

A

Henderson-Hasselbalch Equation

21
Q

actual pH < pKa

A

Protonated

22
Q

actual pH > pKa

A

Unprotonated

23
Q

A mixture of a weak acid and its conjugate base that can resist a change in pH when protons are produced or consumed

A

Buffer Solution

24
Q

Maximum buffering occurs at

A

pKa ± 1

25
Q

Physiologic Buffers

A

bicarbonate, proteins, orthophosphate

26
Q

Most important EXTRAcellular buffer

A

bicarbonate

27
Q

Most important INTRAcellular buffer

A

proteins