I NEVER seem TO remember... Flashcards
List the cardioselective Beta-Blockers –>MAN BABE
Metoproplol
Atenolol
Nebivolol
Bisoprolol
Acebutolol
Betaxolol
Esmolol
What is the most common tachydysrhythmia seen in patients with WPW syndrome?
AVNRT
AVNRT is classified as either
orthodromic (narrow QRS complex)
antidromic (wide QRS complex).
Ortho”dRROW”mic AVNRT is much more common (90%–95% of cases) and has _______(narrow/wide)QRS complex
naRROW QRS complex because the cardiac impulse is conducted from the atrium through the normal AV node–His-Purkinje system.
Orthodromic AVNRT vs Antidromic which is more common ?
Orthodromic AVNRT is much more common (90%–95% of cases
In orthodromic AVNRT, what occurs?
Cardiac impulse is conducted from the atrium through the normal AV node–His-Purkinje system. These impulses return from the ventricle to the atrium using the accessory pathway.
In antidromic AVNRT, what occurs?
In the less common antidromic form of AVNRT the cardiac impulse is conducted from the atrium to the ventricle through the accessory pathway and returns from the ventricles to the atria via the normal AV node
What drugs are contraindicated with antidromic form of AVNRT? why?
Drugs that SLOW AV nodal conduction (BAC- LiDig)
β-blockers, Adenosine Calcium channel blockers Lidocaine Digoxin
Because they may increase conduction along the accessory pathway and are contraindicated.
Multifocal atrial tachycardia (MAT) is most commonly seen in patients experiencing
an acute exacerbation of chronic lung disease.
Treatment of antidromic AVNRT in patients with stable vital signs includes
IV administration of procainamide 10 mg/kg IV infused at a rate not to exceed 50 mg/min.
Treatment of orthodromic AVNRT in conscious patients in stable condition should begin with
vagal maneuvers such as carotid sinus massage or a Valsalva maneuver.
If vagal maneuvers are unsuccessful in a patient with AVNRT,–> VABA
Verapamil
Adenosine
β-blockers
Amiodarone may be used as clinically appropriate.
Wolff-Parkinson-White (WPW) syndrome is an inherited disorder characterized by
reentrant tachycardias.
The diagnosis of WPW syndrome is reserved for conditions characterized by
both preexcitation and tachydysrhythmia.
In WPW , Ventricular preexcitation causes an earlier-than-normal deflection of the QRS complex called a
delta wave.
ECG changes indicative of new ischemia
new ST-T changes,
new left bundle branch block
CABG is preferred over PCI in patients with
- significant left main coronary artery disease
- 3- vessel CAD
- patients with diabetes mellitus who have two- or three-vessel coronary artery disease.
Levels of cardiac troponins (troponin T or I) increase within_____hours
3 hours after myo- cardial injury and remain elevated for 7–10 days
Levels of cardiac troponins (troponin T or I) remain elevated for how long after MI
7-10 days
The criteria for the definition of an AMI have been revised Now this diagnosis requires detection of a rise and/or fall in cardiac biomarkers (preferably troponin with at least one value above the 99th percentile of the upper reference AND what?
(1) symptoms of ischemia
(2) ECG changes indicative of new ischemia, such as new ST-T changes or new left bundle branch block (LBBB)
(3) development of pathologic Q waves on the ECG, or (4) imaging evidence of a new loss of viable myocardium or a new regional wall motion abnormality.
Reperfusion / Thrombolytic therapy with tissue plasminogen activator (tPA) such as (name 3 )
alteplase, reteplase, or tenecteplase
Thrombolytic therapy with tissue plasminogen activator (tPA) should be initiated when?
should be initiated within 30–60 minutes of hospital arrival and within 12 hours of symptom onset.
The primary goal in management of STEMI is to
reestablish blood flow in the obstructed coronary artery as soon as possible.
What may be preferable to thrombolytic therapy for restoring flow to an occluded coronary artery if appropriate resources are available?
PCI
What are the 2 most common atrial dysrhythmias seen with AMI?
Atrial fibrillation and atrial flutter
The classic presentation is a hypercyanotic spell (“tet spell”) during which profound
cyanosis develops rapidly, accompanied by hyperpnea, possible loss of consciousness, stroke, seizures, or even death.
Treatment of tet spells
Treatment focuses on relieving the RVOT obstruction and reversing (or ameliorating) the right-to-left shunt.
Acute or emergent treatment entails (in escalating order) administration of 100% oxygen, fluid administration, and positioning (bending at the hip or gentle pressure on the abdomen
Absolute Indications for Lung separation
A. Isolation of one lung from the other to avoid spillage or contamination (INFECTION and MASSIVE Hemorrhage)
B. Control of the distribution of ventilation: Bronchopleural fistula, Bronchopleural Cutaneous fistula, Surgical opening of major conducting airway
Giant unilateral lung cyst or bulla relative vs absolute OLV
Absolute
Unilateral bronchopulmonary lavage 1. Pulmonary alveolar proteinosis: relative vs absolute OLV
Absolute
Relative indication for one-lung ventilation (OLV)
-
Surgical exposure—high priority*
1. Thoracic aortic aneurysm 2. Pneumonectomy
3. Thoracoscopy
4. Upper lobectomy
5. Mediastinal exposure
Absolute OR relative OLV –> –Postcardiopulmonary bypass pulmonary edema/hemorrhage after removal of totally occluding -unilateral chronic pulmonary emboli.
All Relative contraindication
The most common complication associated with a DLT is _______
malpositioning
Mediastinal Masses: What is the major anesthetic goal?
to maintain spontaneous ventilation, which retains normal airway-distending pressure gradients and can maintain airway patency when positive-pressure ventilation will not.
Left axis deviation is associated with what kind of fascicular block?
RIGHT axis deviation is associated with what kind of fascicular block?
Left axis –> LAft ANTERIOR Fascicular block
Right axis –> Left POSTERIOR Fascicular (LA-RP)
What is the most common hemiblock?
Left anterior fascicle (LAHB)
Why is a LEFT POSTERIOR HEMIBLOCK is uncommon when compared to LEFT ANTERIOR hemiblock?
Left posterior hemiblock (LPHB) is uncommon because the posterior fascicle of the LBB is larger and better perfused than the anterior fascicle.
Criteria for RBBB
widened QRS complex (≥120 ms in adults)
rSR′ configuration in leads V1 and V2
Deep S wave (>40 ms) in leads I and V6.
Criteria for LBBB
QRS complex of longer than 120 ms in duration in the -absence of Q waves in leads I and V5 and V6, a broad notched or slurred R wave in leads I, aVL, V5, and V6.
Crossmatching blood involves
mixing the blood of the donor and recipient together in the lab
What are 2 indications for lung transplantation?
Both cystic fibrosis and sarcoidosis
Which surgical procedure is most commonly associated with chronic postsurgical pain (CPSP)?
Thoracotomy
The most reliable stimulator of arousal in persons with obstructive sleep apnea is
Work of breathing
Which epidural needle has wings at the hub in order to stabilize the needle and assist grip during insertion?
Weiss
Where in the nephron do thiaziDe diuretics work? and how?
Thiazide diuretics work in the EARLY distal tubule by interfering with this sodium-chloride pump.
Part of the nephrons that contains sodium-chloride transporters that move sodium chloride out of the filtrate into the cells of the tubule walls.
The early distal tubule
During two-lung ventilation, about _____% of the pulmonary blood flow goes to the dependent lung. Therefore, when one-lung ventilation is instituted, you would expect the patient to experience approximately a____% shunt as blood that is unable to be oxygenated travels through the nondependent lung.
60% ; 40%
The recommended initial treatment for portal hypertensive ascites is
salt restriction (2 g/day) and diuretics.
Gas exchange occurs in the airways across which type of cells?
Squamous epithelial
Thiazide-type diuretics include: (MICH)
Metolazone
Indapamide
Chlorthalidone,
Hydrochlorothiazide
Spironolactone and eplerenone inhibit the hormone aldosterone directly in the
collecting duct
Amiloride and triamterene inhibit the opening of sodium channels where?
collecting duct, which blocks sodium reab- sorption and potassium secretion.
Examples of loop diuretics include: BEF-TO
bumetanide
ethacrynic acid,
furosemide
torsemide.
Loops diuretics work how and where in the nephron?
Inhibit sodium and chloride reabsorption at the Na+-K+-2Cl− channel in the thick ascending limb of the loop of Henle.
Intravascular injection of epinephrine 10 to 15 mcg/mL in adults produces a
10-beat or greater heart rate increase, or a 15 or greater mm Hg systolic blood pressure (SBP) increase in the absence of BAAG (β blockade, active labor, advanced age, or general/neuraxial anesthesia)
• Intravascular injection of epinephrine 0.5 mcg/kg in children produces a__________ in SBP
15 or greater mm Hg increase in SBP.
What can produce sedation if injected intravascularly in laboring patients.
• Fentanyl 100 mcg
The minimum recommended seizure duration for ECT is
25 seconds.
What nerve fibers are thought to exhibit dysfunctional activity in the setting of neuropathic pain? (select two)
A and C fibers
The most common congenital abnormality that can result in aortic dissection is
Bicuspid aortic valve
Tricuspid atresia is a congenital heart defect that is characterized by a (SEDPA)
Small right ventricle
Enlarged left ventricle
Decreased pulmonary blood flow (that occurs via a
ventricular septal defect,
Patent ductus arteriosus, or bronchial vessels)
Arterial hypoxemia
The recommended maximum leakage current allowed in operating room equipment is:
10 μA
Bupi- vacaine or ropivacaine, in concentrations of 0.125% to 0.5%, are usually administered with epinephrine 1 : 200,000, to a maximum dose of
2.5 mg/kg body weight.
A normal anion gap acidosis is often called a.
hyperchloremic metabolic acidosis
The 2 most common causes of a normal–anion gap acidosis are
IV infusion of sodium chloride
GI and renal losses of bicarbonate (diarrhea, renal tubular acidosis, early renal failure).
The most common cardiac side effects of tricyclic antidepressants are
increased heart rate and orthostatic hypotension.
What congenital disorder is highly suspected if maternal polyhydramnios is present?
TEF
Contrast-induced nephropathy is defined as an increase in serum creatinine of _____ mg/dL or a ____ percent increase from the baseline within the first 24 hours.
0.5 mg/dL; 25 percent
Hypoplastic left heart syndrome is characterized by 5 things? What are they ? Extracardiac congenital anomalies are typically ________
Left ventricular hypoplasia
Mixing of systemic venous and pulmonary venous blood in a single ventricle which communicates directly with the pulmonary and systemic circulatory systems, Hypoplasia of the ascending aorta
Mitral valve hypoplasia
Aortic valve atresia.
not present.
With Hypoplastic left heart syndrome, there is a Rapid decreases in _____ that can result in a
PVR; Decrease in coronary and systemic blood flow Metabolic acidosis High-output cardiac failure Ventricular arrhythmias.
The veins that contribute to the hepatic portal vein include:
- superior mesenteric vein 2. inferior mesenteric vein 3. Splenic vein.
The renal veins drain into the
inferior vena cava.
Preterm infants often display hyperkalemia. The causes of this are principally related to (select two)
immature distal tubule function
relative HYPOALDOSTERONISM
Nearly all of the skin of the leg is innervated by the _______nerve.
sciatic
When inserting an Eschmann stylet during intubation, the stylet should be advanced into the trachea until
the 25 cm marking is at the lip????
COMMON GIVEN MEDICATION Avoided preoperatively in the patient with significantly increased intracranial pressure?
MIDAZOLAM
The contraction of the gallbladder is primarily stimulated by the release of
CHOLECYSTOKIN
Cortisone has a _____short half-time of only _____
very; only 30 minutes.
Triamcinolone, betamethasone, and dexamethasone have elimination half-times between
3.5 and 5 hours.
Which of the following substances is the principal neurotransmitter in the activation of dorsal horn neurons following painful stimuli?
Glutamate
A 56-year-old man is undergoing a right carotid endarterectomy with intraoperative EEG monitoring. Which of the following cerebral blood flow rates BEST defines the range where signs of ischemia first appear on EEG?
15-20 mL/min/100 gm
12 French catheter would have an outer diameter of
To determine the outer diameter of the French gauge system, the French gauge is divided by 3, and the answer will be in millimeters. Therefore, a 12-Fr catheter would have an outer diameter of 4 mm.
Portal hypertension is defined as a
hepatic venous pressure gradient (HVPG) greater than 5-6 mmHg,
Hepatic venous pressure gradient (HVPG) is calculated by the calculating the
difference between portal and hepatic vein pressure.
Portal hypertension results in 6 things: Name 2 LESS OBVIOUS
ascites formation of varices hepatorenal syndrome splenomegaly ***splanchnic vasodilation*** ***gastropathy****
HVPGs in excess of_____ mmHg place the patient at risk for variceal bleeding.
12
Where does Aldosterone work in the nephron?
CD
Collecting duct
Distal tubule
What is the predisposing factor doubles the risk of bladder cancer?
Smoking
The mainstay of treatment of disseminated intravascular coagulation is the administration of
FFP
Can infrared gas analyzers directly measure oxygen content?
NO
It is an INTRAumbilical abdominal herniation in pediatrics
omphalocele
Associated with projectile vomiting in pediatric
Pyloric stenosis
Factors decrease in pregnancy
11 and 13 (XI and XIII) (think decrease pregnancy risk in 11 and 13 yrs old)
Factors UNCHANGED in pregnancy
2, 5 (II, and V)
It is (also known as congenital aganglionic megacolon) in pediatrics
Hirschsprungs disease
It is a lack of parasympathetic ganglion cells in the large intestine with resulting distention of the colon and intestinal obstruction in pediatrics?
Hirschsprungs disease
It is lateral to the umbilicus (usually to the right side) of pediatric patients? (GI condition)
gastroschisis
It is an PERIumbilical abdominal herniation in pediatrics
Gastrochisis
The gallbladder normally stores about _____ mL of bile.
50
Which of the following Acid / base abnormality is associated with hypoaldosteronism?
Hyperchloremic metabolic acidosis
At birth, the T waves are_______ in all chest leads, but become isoelectric or inverted in leads V1-V4 by when? .
upright; one week of age. They remain isoelectric or inverted until adolescence when they become upright again.
Failure of the V1-V4 T waves to invert by one week of age can indicate
right ventricular hypertrophy.
Which Laminae are located in the dorsal horn of the spinal column.
Rexed laminae I through laminae VI
Which laminae are located location in the comprise the ventral horn.
Laminae VII, VIII, and IX
When you see a question about shunt or venous admixture, think about _____. Explain.
FRC.
When your FRC is less, the amount of pulmonary blood that comes into contact with oxygenated alveoli per unit time is DECREASED which INCREASES the venous admixture (shunt)
In the clinical, when FRC is decreased the patient is at risk for rapid _________and the A-a gradient is
Desaturation ; INCREASED
% of RV in total lung capacity
20%
How much oxygen is consumed by a 70kg healthy adult at rest? Give your answer in ml/100g/min
Classic formula is 3.5 ml/kg/min
Classic answer of O2 consumption at rest for a 70kg adult is
250 mL/min
Phenomenon responsible for tachypnea that accompanies pulmonary embolism
J receptor stimulation
Phenomenon responsible for tachypnea that accompanies vascular congestion such as CHF
J receptor stimulation
Stop inspiration when lungs is hyper inflated?
Hering Bruer Inflation reflex
Peak effect of HPV
15 minutes
HPV inhibited by
Vasodilators
HPV inhibited by 3 med classes
Vasodilators,PDE inhibitors, CCBs
HPV during OLV is effective in decreasing the cardiac output to the nonventilated lung by approximately
50%
During * two-lung* ventilation, blood flow to the dependent lung averages approximately
60%
During OLV Without autoregulation of pulmonary blood flow, a ___% shunt would be anticipated.
40%
HPV is a reflex intrapulmonary feedback mechanism in homogeneous lungs that does 2 main things?
Improves gas exchange
Improves arterial oxygenation.
Hypoxemia causes________ (dilation vs constriction) in the general circulation
vasodilation
Alveolar hypoxia effect on pulmonary arteries.
Vasoconstriction
HPV can increase the PVR by
50% to 300%, and the response can persist for long periods of time in the face of chronic hypoxia
HPV occurs whether the lung is rendered hypoxic by atelectasis or by ventilation with a hypoxic mixture. It is initiated within _______and reaches its maximum effect in approximately
seconds of hypoxia; 15 minutes.
HPV improves arterial oxygenation when the amount of hypoxic lung is between____and ____%
20% and 80%, which occurs during OLV.
*****Factors That Reduce Effectiveness of Hypoxic Pulmonary Vasoconstriction. (4HA PEAS)
- Hemodilution
- Hypervolemia (LAP > 25 mm Hg), atrial natriuretic peptide
- Hypocapnia
- Hypothermia
- Prostacyclin
- Excessive tidal volume or PEEP
- Alkalosis
- Shunt fraction < 20% or > 80%
*****Medications that Reduce Effectiveness of Hypoxic Pulmonary Vasoconstriction (VCV 1.5 P)
Vasodilators
Calcium channel blockers
Volatile anesthetics > 1.5 MAC
Phosphodiesterase inhibitors
Hypoxemia when Oxygen does not help?
Right to left shunt (VET) : VSD, Eisenmenger, Tetralogy
The single best predictor of post operative PULMONARY complications is
VO2 max (also hypoalbuminemia and INCREASED BUN are able to do so)
Pneumonectomy, how much fluid to be given within the first 24 hours?
< 3L
Best predictor test of airflow in the medium size airways?
MMEF
Normal MMEF is
> or equal to 75%
Severe MMEF is
less or equal to 30%
What is the 2 most common ABG finding during an asthmatic attack are
Hypocarbia
Respiratory Alkalosis.
When does CO2 retention starts doing an asthmatic attack?
When FEV1 < 25% and it is a sign of IMPENDING RESPIRATORY FAILURE
FEV1 in asthmatic that indicates impending respiratory failure is
FEV1 < 25%
What does the diffusion capacity for carbon monoxide measure?
How well the lung can exchange gas.
DLCO measures the partial pressure
Different between the inspired and expired CO after a known quantity of CO has been inhaled
What is a normal DLCO?
17-25 ml/CO/min/mmHg
DLCO : higher/lower values correlate with a
significant reduction in diffusing capacity.
DLCO Using this law
Fick’s law of diffusion
Using Fick’s law of diffusion, the DLCO tell us 2 key characteristics about the alveolocapillary interface, what are they?
Surface area (emphysema) Thickness (increased by fibrosis and pulmonary edema)
Does asthma affect DLCO
NO
Chronic Bronchitis : what happens to Blood?
Polycythemia
Increased RBC mass compensates for chronically low PaO2 (tend to retain CO2 (BLUE BLOATERS)
Which heart issue is common with chronic bronchitis, what is it a result of ?
Right heart failure, results of pulmonary HTN (think all signs of RV failure)
With pulmonary embolism prevents
Blood in the affected vessels form reaching the
Best ventilatory strategy for restrictive lung disease ?
Smaller TV 6 ml/kg/IBW
Faster RR 14-18 breaths/min
There are five causes of hypoxemia, which ones are associated with normal A-a gradient?
- High altitude
2. Hypoventilation
There are five causes of hypoxemia, which ones are associated with INCREASED A-a gradient?
Diffusion defect
V/Q mismatch
Right to left shunt (O2 not helpful)
What is an example of acute intrinsic restrictive lung disease>
Negative pressure pulmonary edema
Flail chest chest movement during inspiration and expiration?
Inward during inspiration
Outward during expiration.
Best measurement of gas EXchange
DLCO
Best measurement of RESPIRATORY MECHANICS
FEV1
Best measurement of cardiorespiratory interaction is
VO2 max
6 steps (in order of preference) to reverse hypoxemia during OLV. (FDC- PLR)
FIO2 to 100% DLT position check with fiberoptic CPAP 10cm H2O non-dep lung PEEP 5-10 dependent lung Ligate/clamp pulmonary artery of non-dependent lung (not always poss) Resume 2-lung ventilation
What are the 2 CLINICALLY SIGNIFICANT examples of the baroreceptor reflex during surgery include
- Carotid sinus manipulation reflex during CEA (carotid endarterectomy.)
- Aortic baroreceptor stimulation from pressure exerted on the aortic arch during mediastinoscopy
During mediastinoscopy, which receptor can be stimulated?
Aortic baroreceptor stimulation from pressure exerted on aortic arch
Mediastinoscopy which site for aline monitoring and why?
Right radial because it provides indication of innominate artery
5 possible complications of mediastinoscopy?
hemorrhage Pneumothorax dysrhythmias (bradycardia) bronchospasm Left RLN Laceration of trachea or esophagus
Chylothorax from mediastinoscopy can occur secondary to
Laceration of the thoracic duct
Mediastinoscope can put pressure on the
Innominate (brachiocephalic artery) prior to its division to right common carotid and right subclavian artery>
2 things that can be played to monitor perfusion to Right arm during mediastinoscope
Pulse ox or radial artery catheter (a-line)
All sympathetic neurotransmitters are synthesized from _______ The synthesis takes place where ?
tyrosine ; in the post-ganglionic sympathetic nerve ending.
What is the local anesthetic that is prolonged the most by adding an adrenergic agonist.
Tetracaine
Which endotracheal tube is designed to deflect laser beams?
Mallinckrodt tube
Constrast-induced neuropathy is can be seen with 2 changes from the baseline what are they?
Serum Creatinine increase by 0.5
BUN increase by 25%
At what blood carboxyhemoglobin level is hyperbaric oxygen indicated?
> 30%
In the brain, As the MAP decreases within this autoregulation range, the cerebral vessels
dilate to keep CBF constant. (DD : decrease, dilate)
During renal transplant, where is the donor kidney anastoamosed?
The donor kidney is anastamosed to the recipient’s external iliac artery and vein
When the glomerular filtration reaches____of normal, serum potassium begins to elevate.
10%
the QRS axis is_____-sided at birth
right; It shifts leftward by about one month of age. The T waves are upright in all chest leads at birth, but become isoelectric or inverted in leads V1-V4 by one week of age
Barbiturates on cerebrovascular resistance
INCREASES cerebrovascular resistance
One way to estimate the approximate MAC of an agent is to divide
150 by the oil:gas coefficient. In this case, 150 divided by 100 would equal an estimated MAC of 1.5%.
The secretion of hydrogen ions and reabsorption of bicarbonate ions occurs all along the tubules with the exception of the
thin segments of the loop of Henle
Deleterious effects of hypothermia include:
Effect on hemoglobin-oxygen saturation Curve
left shift of the hemoglobin-oxygen saturation curve
Deleterious effects of hypothermia include:
Effect on Platelet
reversible platelet dysfunction
Deleterious effects of hypothermia include: Effect on wound
poor wound healing
increased incidence of infection
Deleterious effects of hypothermia include: Effect on Heart
cardiac arrhythmias
increased PVR
Deleterious effects of hypothermia include: Effect on Protein
postoperative protein catabolism
Deleterious effects of hypothermia include: Effect on drug metabolism
decreased drug metabolism
Deleterious effects of hypothermia include: mental status
altered mental status
Deleterious effects of hypothermia include: Effect on Kidney
impaired renal function
What is the Formula for Closing Capacity?
Closing volume + Residual volume
The closing volume does increase from approximately of ____% of the TLC at age 20 years to approximately at ______%age 70 years
30% ; 55%
CO2 solubility is _____ mL
0.06 mL
This reaction : CO2 + H2O ↔ H2CO3 ↔ H+ + HCO3- is catalyzed by which enzyme? Where does this reaction occurs? and is it slower or faster and why?
Carbonic anhydrase;
Outside the RBC’s, in the plasma, but it is much slower due to lack of CA.
CO2 dissociation curve and INHALED anesthetics effect? What about HIGH concentration of inhaled anesthetics?
All inhaled anesthetics depress the ventilatory response to hypercarbia in a dose-dependent fashion.
High concentrations of volatile anesthetics may almost entirely eliminate hypercarbia-induced increases in ventilatory drive.
The response of two common classes of IV anesthetics are subtly different – OPIOIDS create a_______ward-shift in the CO2 response curves, whereas benzodiazepines and propofol affect the slope?
Right (OPIOIDS)
Left (Benzodiazepines and Propofol) ; decrease the slope
How does Hypoxemia affect the CO2 dissociation curve?
Hypoxemia (paO2 < 65 mm Hg) leads to a LEFT-shift in the CO2 response curve.
What are other two causes of left-shift of the CO2 curve?
metabolic acidemia and central etiologies
Both of the medications that decrease the slope of the ventilatory response curves
Propofol
Benzodiazepines
Inspiration of CO2 in the alert and awake patients ventilatory response.
carbon dioxide in healthy, awake subjects INCREASES minute ventilation by approximately 3 L/min per 1 mm Hg of arterial carbon dioxide tension
CO2 dissociation curve as compared to the O2 dissociation curve
The CO2 dissassociation curve is linear in shape and steep compared to O2 dissociation curve
What is the appropriate mainstay of initial perioperative management in patients with carcinoid tumors?
somatostatin analog therapy
Carcinoid tumors release a variety of subtances (ex. serotonin, catecholamines, histamine) which can cause both
hypertension and hypotension.
How do you treat Hypotension in the patients with carcinoid tumors?
vasopressin (β-agonists may increase the release of vasoactive substances) or phenylephrine
How do you treat Hypertension in the patients with carcinoid tumors?
α and β-adrenergic receptor blockers
Clonidine has intrinsic ability to block conduction in ____- AND____FIBERS
C and Aδ fibers
A single induction dose OF ETOMIDATE may inhibit THIS ENZYME LEADING TO _______how long does it last
11β-hydroxylase ⇒Adrenocortical suppression
4-8 hours
Etomidate on EEG
initial increase α amplitude followed by progressive decrease in activity
The transplanted kidney is attached to the recipient’s vasculature via _____________ (which artery and vein) and the ureter is anastomosed
- **vascular anastomoses of the external iliac artery and vein
- *directly to the bladder
Why do many transplant recipients require a central line?
because of the administration of immunosuppressive and vasoactive medications.
2 medications that are calcineurin inhibitors used post transplant
Cyclosporine
Tacrolimus,
MOA of Calcineurin inhibitors?
Both Inhibits calcineurin and IL-2 production
Patients with ESRD are at risk for aspiration due to
Gastroparesis
What is the primary stimulus for the release of aldosterone by the adrenal cortex?
Angiotensin II
Aldosterone results in increased
sodium and water retention.
The circle system test evaluates the circle breathing system from the
common gas outlet to the y-piece and consists of two parts, the leak test and the flow tes
The hanging drop technique is used to verify that the epidural needle has passed through the
ligamentum flavum into the epidural space.
Write the SODA lime equation
- CO2 + H2O ↔ H2CO3
- H2CO3 + NaOH ↔ Na2CO3 + H2O + energy
- Na2CO3 + Ca (OH)2 → CaCO3↓ + NaOH
Water content of the Soda lime is
15-20%
Last phase of the soda lime
Na2CO3 + Ca (OH)2 → CaCO3↓ + NaOH
Baralyme + Sevoflurane leads to
FIRE
What 2 things reduce the production of Compound A
Addition of Ca(OH)2
removal of NaOH
High pressure system include
Back up cylinders
Cylinders yoke
Cylinder gauge
Cylinder regulator
Monitor lead ____for rhythm, and ____for ischemia
II;
V5
Anterior Axillary line
Nagelhout says V1-V2 to be placed at
4th ICS
Nagelhout says V4-V5 to be placed at
5th ICS
Intermediate pressure system include
Pipeline inlet Check valves Pressure gauges Ventilator power inlet Oxygen pressure system
FLOWMETER CONTROL VALVE is part of _______pressure system
Intermediate
Pipeline inlet is part of the
Intermediate pressure system
Oxygen 2nd stage regulator is part of the
Intermediate pressure system
Oxygen flush valve is part of the
intermediate pressure system
Part of the Low pressure system
Flowmeters
Vaporizers
Common gas outlets
Check valves (if present)
Higher temperature leads to ______vapor pressure
Higher VP
SA node primarily in 55% of us
RCA
AV node primarily in 90% of us
RCA
AV node is supplied by the RCA in
90% of people
SA node is supplied by the RCA in
55%
When ambient temperature goes high, what happens to fresh gas flow and the vaporizing chamber/ bypass chamber?
Less fresh gas flow to the VAPORIZING CHAMBER
More Fresh gas flow to the BYPASS CHAMBER
High pressure system begins and ends where?
Begins at the cylinder
Ends at the cylinder regulators
Intermediate pressure system begins and ends where?
Begins at the pipeline
Ends at the flowmeter valve
Intermediate pressure system begins and ends where?
Begins at the pipeline
Ends at the flowmeter valve
Low pressure system begins and ends where?
Begin at the flowmeter tubes
Ends at the common gas outlet
Best test to determine the vaporizer leak is
The negative pressure test
Low pressure leak test measure what?
Integrity of the low pressure circuit from the flowmeter valve to the CGO
Low pressure system fails if the bulb inflates within _____seconds
10
Low pressure leak test is the _____pressure test
NEGATIVE
For the low pressure leak test, If there is a minimum FGF when the machine is turned on, then what should be done
the machine must be turned On
With the pressure leak test, the FGF and ventilator must be on/off?
off
With the pressure leak test, should the vaporizer be on or off, explain
Should be off at first, then the test should be repeated as each vaporizer is turned on. The negative pressure test is best way of detecting a vaporizer leak
The high pressure leak test is conducted how?
Closing APL
Pressurize circuit to 30cm H2O
Observe the airway pressure gauge (should remain constant)
With the high pressure leak test, what determines which components of the low pressure system are test?
The presence or absence of a check valve.
Nagelhout proper placement of V5
Horizontal to V4 on the ANTERIOR AXILLARY line; or, if the anterior axillary line is difficult to identify, then midway between V4 and V6
So if you open a cylinder and you hear a hissing sound, what is it ? what should you do?
There is a leak
Tighten the connection.
Non metallic cylinder box is
Aluminum
Max temperature gas cylinder
130F (57C)
Fusible plug up made up of BLT
Bismuth
Lead
Tin
Cylinders must be checked every
5 years
Set Standards for compressed gas cylinder
US DOT
Pre-use checkout procedures created by
FDA
Set required components of anesthesia machine
American society for testing and material
Oiling valve increases risk of
Fire
Cracking a cylinder means
slowly opening the cylinder flush the valve outlet clean of dust and debris.
Oxygen fail safe device what oxygen pressure will completely stop the flow of N20?
< 20 psi
HYPOXIA prevention safety device is a
Proportioning device
It prevents you from setting a hypoxic mixture with the flow control valves.
The annular space is the
area between the WIDEST AREA of the indicator float and side wall of the flowmeter
Left axis deviation is
-45 to -90
Reynolds’ number formula
Density x diameter x velocity/ viscosity
How to calculate Fresh gas coupling
- first convert FGF from L/min to ml/min
- I:E ratio of 1:2 would be 20 seconds in inspiration and 40 seconds in expiration so 1/3 of time in inspiration SO –> 1/3 of the ml/min value
- Divide the ml/min value by the RR
- Add the results of step 3 to the TV
If compliance and peak pressure are given multiople
compliance by peak pressure then substract number from TV.
Variable bypass 4 things to think about ?
Flow over
Temperature compensated
Out of circuit
Agent specific
Determines splitting ration
Concentration set on the dial
Most common cause of a vaporizer leak
loose filler cap
ml of liquid anesthetic used an hour
Vol % x FGF x 3
Types of oxygen analyzers that must be calibrated daily
Galvanic fuel Cell
Types of oxygen analyzers that must is self-calibrating
Paramagnetic device
Oxygen analyzers resides in the _______limb
Inspiration
Increasing oxygen tension generates a current accross 2 electrodes? what type of oxygen analyzers
Galvanic Fuel cell
IS calcium a TREATMENT for hyperkalemia?
No , it stabilizes the membrane till you can treat
Sugammadex in order of affinity to NMB
Roc, vec, pancuronium
At what pH does ethyl violet change to purple
10.3
How many Kilocalories calories with each breath?
1.67 Kcal/breath
Exelon patch should be off _______
24 hours
Prolong effect of rocuronium
Dehydration
Labetalol Beta to alpha
7:1 beta to alpha
Control sympathetic output beta blocker
esmolol
Post op shivering treatment
Meperidine and Clonidine
Clonidine: and warming?
Inhibit warming patient may be shivering
ACE Inhibitors overdose antidotes : Name 2?
methelyne BLUE
NOREPINEPHRINE (BEST ANSWER, nitric oxide inhibition)
Hydralazine onset
10-15 minutes
Cyanide toxicity medication
Nitroprusside
Clinical manifestations of neonates born with congenital diaphragmatic hernia include
Dyspnea
Absent breath sounds on the affected side, a
Barrel-shaped chest
Scaphoid abdomen
Tachypnea
Dextrocardia
Severe retractions.
Clevidipine contraindicated in
Aortic Stenosis.
ARBs major side effect
Hyperkalemia
The pediatric dose of intranasal midazolam is
0.1-0.2 mg/kg.
After 2 PRBCs you should give
Calcium
Heparin needs
AT III
Pradaxa inhibits factor
X
Antithrombin III deficiency give
FFP
A peripheral nerve stimulator used to assess neuromuscular blockade is designed to produce what type of wave signal?
monophasic, square wave signals
Vitamin K dependent factors?
2, 7, 9 10 Protein C, Protein S
TXA inhibits conversion of
Plasminogen to plasmin
TXA inhibits conversion of
Plasminogen to plasmin (and plasmin itself dissolves clot)
Which of the following are known side effects of the use of fenoldapam as an agent for producing controlled hypotension?
Increased intraocular pressure
extrusion of the abdominal contents into the extraembryonic coelom is known as
Omphalocele
Tumescent lidocaine max
50-55mg/kg
Max dose of bupivacaine
2.5mg/kg without EPI (3mg/kg WITH EPI)
PONV dose of epinephrine
0.5 mg/kg
Chloroprocaine pka is high but still works fast why?
because of high concentrations
Contact with birds may contract _______pneumonia.
Chlamydia
Cancer medication Tamoxifen associated
Hypercalcemia (think Camoxifen)
Cancer medication Tamoxifen associated
Hypercalcemia; venous thrombosis.
Cancer medication Bleomycin associated
Pulmonary Fibrosis
Cisplatin side effects
ototoxicity and renal failure
Mitomycin side effects
hemolytic uremic failure and cardiac failure,
Which of the following interventions should be avoided in an infant with a congenital diaphragmatic hernia?
MASK VENTILATION –> stomach inflation and worsen mediastinal displacement.
Cirrhosis is associated with
Comment on : Na, albumin, anemia, Platelets, Bilirubin
Hyponatremia Hypoalbuminemia. Anemia Thrombocytopenia Hyperbilirubinemia
According to the standards set by the American Society for Testing and Materials (ASTM), a reservoir bag of ____liters that is distended to ____times its size shall not exert pressures that are (select two) less than ______or greater than ____
3L
four times
Less than 35 cm H20
Greater than 60 cm H2O
Tension pneumothorax percussion :
Hyperresonance to percussion
In what rexed laminae does the 2nd order neurons reside
Lamina V
When a GAS embolism is suspected, the patient should be placed in the
left lateral decubitus position. This is called the Durant Maneuver.
An increased BUN:creatinine ratio is consistent with
Decreased blood volume
Underdosing can lead to myasthenic crisis
Pyridostigmine
only cells in the renal tubules that do not synthesize ammonia to be used in the buffer system are the epithelial cells in the
Loop of Henle
What anatomic structures collect urine from the papilla and funnel it into the renal pelvis?
Major and minor calyces
Forced air warmers transfer heat to the patient via
convection.
Heat lamps and radiant heaters use
radiation.
Resistive heaters (such as warming blankets) use
conduction.
Resistive heat devices such as a heating blanket transfer heat via
conduction.