Hypothyroidism - Darrow Flashcards

1
Q

myxedema

A

lymphedema with accumulation of GAGs in skin with doughy feeling

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2
Q

hypothyroid in children

A

iodine deficiency

congenital defects

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3
Q

hyponatremia

A

hypothyroid

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4
Q

diastolic HTN

A

hypothyroid

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5
Q

Abs to TPO

A

hashimotos

anti-microsomal Abs

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6
Q

subclinical hypothyroidism

A

normal T4 but high TSH

risk for elevated lipids - CHF and areriosclerotic heart disease

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7
Q

yes for tx of subclinical hypothyroid?

A

TSH >5 if anti-TPO present

TSH >10 if no Abs

pregnant patients with TPO Abs and TSH >2.5

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8
Q

causes of hypothyroid

A
hashimotos
RAI induced
subacute lymphocytic
lithium, interferon, amiodarone
hepatitis C
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9
Q

other autoimmune diseases with hashimotos

A
addisons
hypoPTH
DM
PA
sjogrens
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10
Q

fatigue, hyporeflexia, dry skin, loose stools, iron defiency anemia, amenorrhea, neuropathy, purpura

A

hashimotos with celiac disease

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11
Q

carpal tunnel syndrome

A

tinels sign positive

with hypothyroid

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12
Q

systolc ejection murmur at base with high pitched systolic murmur at apex

A

aortic stenosis

aortic sclerosis

with hypothyroid

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13
Q

gallavardin phenomenon

A

dissociation between aortic stenosis murmur

musical at left sternal border and apex

noisy at aortic area

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14
Q

sodium and hypothyroid

A

low - hyponatremia

decreased Na/K ATPase

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15
Q

tx of hypothyroid

A

L-thyroxine start - unless pregnant

maintain euthyroid state

those still tired - check anemia, B12 deficiency, sleep apnea

consider low dose T3

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16
Q

myxedema crisis

A

hypothyroid with stress

20-50% mortality

lethargy/stupor - to myxedema coma

tx - hydrocortisone first
-followed by levothyroxine

17
Q

synthroid

A

levothyroxine - T4

18
Q

dopamine

A

suppresses TSH

19
Q

euthyroid sick syndrome

A

low T3 and high rT3

decreased 5’ deiodinase

increased IL - displaced binding of T4
-decreased total T4 and increased T3 uptake

20
Q

IL-1, IL-6, TNF alpha

A

can cause decreased TSH

21
Q

steroids and dopamine

A

can cause decreased TSH

22
Q

hoarseness, diminished sense of taste and smell, menorrhagia, thinning of lateral 3rd eyebrows, thick tongue, cardiac enlargement, new onset galactorrhea

tx?

A

thyroid replacement

23
Q

TRH additional effects

A

can stimulate prolactin release

so severe hypothyroid - increased TRH - leads to increased prolactin and galactorrhea