Hypothyroidism Flashcards
What is hypothyroidism?
Inadequate output of the thyroid gland
What is the commonest cause of hypothyroidism?
Hashimoto’s thyroiditis
What auto-antibodies are associated with Hashimoto’s thyroidits?
Anti-TPO
Antithryoglobulin antibodies
What medications can cause hypothyroidism?
Lithium
Amiodarone
What is the cause of secondary hypothyroidism?
Hypopituitarism caused by infection, tumours, Sheehan’s syndrome (vascular), radiation
Features of hypothyroidism?
Weight gain (10% weight loss)
Fatigue
Dry skin
Coarse hair
Alopecia
Fluid retention
Heavy/irregular periods
Constipation
Management of hypothyroidism?
Levothyroxine
What is levothyroxine?
Synthetic T4
What are thyroid hormones like in primary hypothyroidism?
Low T4 and T3
High TSH
What are thyroid hormones like in secondary hypothyroidism?
Low T3 and T4
Low TSH