Hypothalamic-Pituitary Hormones effects on other hormones

Question 1

Dopamine

Answer 1

Function: Decrease prolactin release
Notes: Dopamine antagonists used as antipsychotics can cause galactorrhea due to hyperprolactinemia

Question 2

GHRH

Answer 2

Function: increases GH release
Notes: Analog used to tx HIV-associated lipodystrophy

Question 3

GnRH

Answer 3

Function: increases FSH, LH
Notes: Regulated by prolactin, tonic GnRH suppresses HPA axis, Pulsatile leads to puberty, fertility.

Question 4

Prolactin

Answer 4

Function: decreases GnRH
Notes: Pituitary prolactinoma –> amenorrhea, osteoporosis, hypogonadism, galactorrhea

Question 5

Somatostatin

Answer 5

Function: Decreases GH/TSH
Notes: analogs used to tx acromegaly

Question 6

TRH

Answer 6

Function: increases TSH, Prolactin

Question 7

CRH

Answer 7

Function: increases ACTCH/MSH/B-endorphin

Notes: Decreased in exogenous steroid use