Hypothalamic/pituitary/ Gonadal axis

Question 1

what are the 3 organs to the HPG?

Answer 1

hypothalamus
pituitary
gonads

Question 2

you have both positive and negative feedback at the HPG axis. what does this mean in terms of hormone release?

Answer 2

Positive feedback= a positive stimuli from the hypothalamus causes the positive release of a pituitary hormone, which causes the release of a steroid hormone.

Negative feedback= A negative release of pituitary hormones, which decreases the release of steroid hormone.

Question 3

what are steroid hormones?

Answer 3

Group of hormones derived from cholesterol that act as a chemical messenger in the body.

Question 4

what is GnRH and what is its function?

Answer 4

Gonadotrophin releasing hormone= a hypothalamic decapeptide hormone that is released from the pituitary in a pulsatile fashion and controls the synthesis and secretion of LH and FSH from the anterior pituitary.

Question 5

what hormones are released from: Hypothalamus, Anterior Pituitary, and Gonads?

Answer 5

Hypothalamus (releasing hormone)- GnRH and kisspeptin
Pituitary (stimulating hormone)= FSH and LH (peptide hormones)
Gonad= Oestradiol (E2), Progesterone (p4), Testosterone, inhibin and activin
(all steroid hormones produced in both males and females)

Question 6

are inhibin and activin peptide or steroid hormones?

Answer 6

peptide

Question 7

what do inhibin and activin control?

Answer 7

Secretion of FSH from the pituitary

Question 8

what is the function of kisspeptin?

Answer 8

to control the lvls of GnRH

Question 9

what type of hormone is kisspeptin?

Answer 9

peptide hormone