Hypothalamic/pituitary drugs: Prolactin, GnRH, LH/FSH, TRH, and CRH Flashcards

1
Q

What disorders can cause hyperprolactinemia?

A

Pituitary adenomas or diseases that decrease dopamine signaling (parkinson’s)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the effects of hyperprolactinemina?

A
Galactorrhea - women
Amenorrhea - women
Infertility in women/men
loss of libido - men
Impotence - men
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the treatments for hyperprolactinemia?

A
  1. Surgery
  2. Radiation
  3. Dopa receptor agonist
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the D2 receptor agonists?

A

Cabergoline (high affinity)

Bromocriptine (Poorly tolerated)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the normal physiological function of GnRH?

A

GnRH stimulates the release of LH and FSH from the anterior pituitary.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

For what therapeutic uses are exogenous LH and FSH used for?

A

Infertility and hypogonadism in women

Infertility in men.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the Goserelin, Triptorelin, and Leuproloide?

A

They are GnRH agonists used for prostate cancer.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the effects of Goserelin, Triptorelin, and Leuproloide?

A
  1. Increased LH initially

2. decreased LH and testosterone subsequently by decreased receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is HIstareline?

A

GnRH agonist that decreases LH receptors leading to precocious puberty.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is Nafarelin?

A

GnRH agonist used for precocious puberty and endometriosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is different about synthetic GnRH compared to natural GnRH?

A

Synthetic GnRH with aa substitutions that increase its T1/2 and receptors binding affinity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is Human excreted CG?

A

Purified pregnant piss that mimics LH. Typically used to treat infertile women.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is menotropin?

A

Purified old lady piss that contains LH and FSH. IM injections are given to treat infertility in women.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

For what is recombinant FSH used for?

A

To treat infertility in women.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are Certrorelix and Ganirelix?

A

They are GnRH antagonists used for in vitro fertilization. They function by delaying the LH surge and ovulation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is Degarelix?

A

Degarelix is a GnRH-R antagonist that is used to treat prostate cancer.

17
Q

What is Protirelin?

A

Protirelin is hTRH that stimulates the release of TSH from the pituitary. It is used to test thyroid function.

18
Q

What is thyrotropin alpha?

A

Thyrotropin alpha is hTRH that is used diagnostically for thyroglobulin levels.

19
Q

What is corticotropin releasing hormone used for?

A

CRH is used diagnostically to distinguish between Cushing’s disease and ectopic ACTH.