DDP4 inhibitors Flashcards
1
Q
What are examples of DDP4 inhibitors?
A
- Sitagliptin
- Saxagliptin
- Vildagliptin
2
Q
What are contraindications of DDP4 inhibitors?
A
- Pregnancy / breast feeding
- Ketoacidosis (vildagliptin and sitagliptin)
3
Q
When would you be cautious using DDP4 inhibitors?
A
- Elderly
- Renal impairment
- History of pancreatitis
- Hepatic impairment
4
Q
What is the mechanism of action of DDP4 inhibitors?
A
Inhibition of DPP-4 activity causes an increase in incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide) by delaying their breakdown. This increases glucose dependent insulin secretion and reduces glucagon secretion.
5
Q
What are side effects of DDP4 inhibitors?
A
- Gastrointestinal upset
- Oedema
- Hepatic toxicity (vildagliptin)
- Possible increased risk of pancreatitis and pancreatic cancer
- Upper respiratory tract infection / nasopharyngitis
- Stevens-Johnson syndrome
6
Q
Can DDP4 inhibitors cause hypoglycaemia?
A
No
7
Q
A
